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消化管間質腫瘍特異的画像診断ための抗ｃ−ｋｉｔ抗体プローブ開発の試み
https://repo.qst.go.jp/records/69559
https://repo.qst.go.jp/records/695598fb79a44-1000-43cc-825f-2443a069e222
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-31 | |||||
| タイトル | ||||||
| タイトル | 消化管間質腫瘍特異的画像診断ための抗ｃ−ｋｉｔ抗体プローブ開発の試み | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
曽川, 千鶴
× 曽川, 千鶴× 辻, 厚至× 須藤, 仁美× 小泉, 満× 樋野, 興夫× 古川, 高子× 原田, 良信× 佐賀, 恒夫× 曽川 千鶴× 辻 厚至× 須藤 仁美× 小泉 満× 古川 高子× 原田 良信× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Gastrointestinal stromal tumor (GIST) is a most common mesenchymal tumor arising from the gastrointestinal tract. Overexpression of c-kit with its functional mutation is present in most GISTs. Positron emission tomography using 18F-fluoro-deoxyglucose (FDG-PET) has been useful for the detection of GIST and for the assessment of response to Imatinib treatment. However, FDG-PET, in some cases fails to detect relapse of GIST at early stage. If we could develop an imaging method specific to c-kit expression, it can be used for the evaluation of the early relapse of GISTs. In this study, we radiolabeled anti-c-kit monoclonal antibodies (Mabs) with 125I and 111In, and assessed their in vitro and in vivo characteristics. We radiolabeled Mabs with 125I and 111In, and performed cell binding, competitive inhibition and internalization assays in vitro, and biodistribution and SPECT imaging in vivo using tumor-bearing mice. These results showed that radiolabeled Mabs specifically bound to c-kit expressing cells and were internalized, and 111In labeled Mab accumulated in tumors and visualized tumor by SPECT. Radiolabeled anti-c-kit Mab would be useful for the PET/SPECT imaging of GIST. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第67回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-10-30 | |||||
| 日付タイプ | Issued | |||||
