@misc{oai:repo.qst.go.jp:00069559,
 author = {曽川, 千鶴 and 辻, 厚至 and 須藤, 仁美 and 小泉, 満 and 樋野, 興夫 and 古川, 高子 and 原田, 良信 and 佐賀, 恒夫 and 曽川 千鶴 and 辻 厚至 and 須藤 仁美 and 小泉 満 and 古川 高子 and 原田 良信 and 佐賀 恒夫},
 month = {Oct},
 note = {Gastrointestinal stromal tumor (GIST) is a most common mesenchymal tumor arising from the gastrointestinal tract. Overexpression of c-kit with its functional mutation is present in most GISTs. Positron emission tomography using 18F-fluoro-deoxyglucose (FDG-PET) has been useful for the detection of GIST and for the assessment of response to Imatinib treatment. However, FDG-PET, in some cases fails to detect relapse of GIST at early stage. If we could develop an imaging method specific to c-kit expression, it can be used for the evaluation of the early relapse of GISTs. In this study, we radiolabeled anti-c-kit monoclonal antibodies (Mabs) with 125I and 111In, and assessed their in vitro and in vivo characteristics. We radiolabeled Mabs with 125I and 111In, and performed cell binding, competitive inhibition and internalization assays in vitro, and biodistribution and SPECT imaging in vivo using tumor-bearing mice. These results showed that radiolabeled Mabs specifically bound to c-kit expressing cells and were internalized, and 111In labeled Mab accumulated in tumors and visualized tumor by SPECT. Radiolabeled anti-c-kit Mab would be useful for the PET/SPECT imaging of GIST., 第67回日本癌学会学術総会},
 title = {消化管間質腫瘍特異的画像診断ための抗ｃ−ｋｉｔ抗体プローブ開発の試み},
 year = {2008}
}