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L-[11C]methyl-methionine Positron Emission Tomography for Evaluation of Carbon Ion Radiotherapy (CIRT) in Patients with Pelvic Recurrence of Rectal Cancer
https://repo.qst.go.jp/records/69530
https://repo.qst.go.jp/records/6953044ed7e89-7a19-4697-b8de-b9bdd44d6ea0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-22 | |||||
| タイトル | ||||||
| タイトル | L-[11C]methyl-methionine Positron Emission Tomography for Evaluation of Carbon Ion Radiotherapy (CIRT) in Patients with Pelvic Recurrence of Rectal Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koizumi, Mitsuru
× Koizumi, Mitsuru× 小泉 満 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Progress of the novel carbon ion radiotherapy (CIRT) in the treatment of cancers has created the need for a method to accurately evaluate the response. We investigated whether L-[11C]methyl-methionine (11C–methionine) uptake at pre- and post-CIRT could be an early response predictor in patients with pelvic recurrence of rectal cancer. Patients and Methods: 11C–methionine positron emission tomography (PET) was performed prospectively in 53 patients with pelvic recurrence of rectal cancer before and 1 month after CIRT. 11C–methionine tumor uptake was measured by the tumor to muscle ratio (T/M ratio). The T/M ratios were evaluated in relation to clinical outcomes such as local re-recurrence, distant metastasis and survival. The response to CIRT was also judged by computed tomography (CT) and magnetic resonance imaging (MRI). 11C–methionine PET judgment was compared with CT/MRI judgment regarding the relevance to clinical outcome. Results: Baseline T/M ratio was 5.27+/-1.90 (mean+/-SD) in patients without developing local re-recurrence and 7.66+/-3.17 in patients with local re-recurrence (P=0.023, Mann-Whitney U test). Post-CIRT T/M ratios were 3.10+/-1.28 in patients without local re-recurrence and 6.15+/-2.98 in patients with local re-recurrence (p=0.006, Mann-Whitney U test). By Kaplan-Meier analysis with log-rank test, patients with a baseline T/M ratio of <=7.6 or a post-CIRT T/M ratio of <=5.0 had significant lower pelvic re-recurrence. However, the % change (reduction rate) from baseline to post-CIRT T/M ratio did not have significant relation to pelvic re-recurrence. There were no significant differences between 11C–methionine results (baseline T/M ratio, post-CIRT T/M ratio and % change) and other clinical parameters (distant metastasis and survival). Conclusion: 11C–methionine PET can be used for early prediction of local re-recurrence after CIRT. Because CIRT is local therapy, 11C–methionine PET cannot predict distant metastasis or survival after CIRT. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Annual Congress of the European Association of Nuclear Medicine 2008 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-10-15 | |||||
| 日付タイプ | Issued | |||||
