{"created":"2023-05-15T14:50:51.881443+00:00","id":69530,"links":{},"metadata":{"_buckets":{"deposit":"56bbe94f-ea53-41aa-98c4-43c0785e8560"},"_deposit":{"created_by":1,"id":"69530","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69530"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069530","sets":["10:28"]},"author_link":["682372","682371"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Progress of the novel carbon ion radiotherapy (CIRT) in the treatment of cancers has created the need for a method to accurately evaluate the response. We investigated whether L-[11C]methyl-methionine (11C&#8211;methionine) uptake at pre- and post-CIRT could be an early response predictor in patients with pelvic recurrence of rectal cancer.\nPatients and Methods: 11C&#8211;methionine positron emission tomography (PET) was performed prospectively in 53 patients with pelvic recurrence of rectal cancer before and 1 month after CIRT. 11C&#8211;methionine tumor uptake was measured by the tumor to muscle ratio (T/M ratio). The T/M ratios were evaluated in relation to clinical outcomes such as local re-recurrence, distant metastasis and survival. The response to CIRT was also judged by computed tomography (CT) and magnetic resonance imaging (MRI). 11C&#8211;methionine PET judgment was compared with CT/MRI judgment regarding the relevance to clinical outcome.\nResults: Baseline T/M ratio was 5.27+/-1.90 (mean+/-SD) in patients without developing local re-recurrence and 7.66+/-3.17 in patients with local re-recurrence (P=0.023, Mann-Whitney U test). Post-CIRT T/M ratios were 3.10+/-1.28 in patients without local re-recurrence and 6.15+/-2.98 in patients with local re-recurrence (p=0.006, Mann-Whitney U test). By Kaplan-Meier analysis with log-rank test, patients with a baseline T/M ratio of <=7.6 or a post-CIRT T/M ratio of <=5.0 had significant lower pelvic re-recurrence. However, the % change (reduction rate) from baseline to post-CIRT T/M ratio did not have significant relation to pelvic re-recurrence. There were no significant differences between 11C&#8211;methionine results (baseline T/M ratio, post-CIRT T/M ratio and % change) and other clinical parameters (distant metastasis and survival).\nConclusion: 11C&#8211;methionine PET can be used for early prediction of local re-recurrence after CIRT. Because CIRT is local therapy, 11C&#8211;methionine PET cannot predict distant metastasis or survival after CIRT.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Annual Congress of the European Association of Nuclear Medicine 2008","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koizumi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"682371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小泉 満","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682372","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"L-[11C]methyl-methionine Positron Emission Tomography for Evaluation of Carbon Ion Radiotherapy (CIRT) in Patients with Pelvic Recurrence of Rectal Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"L-[11C]methyl-methionine Positron Emission Tomography for Evaluation of Carbon Ion Radiotherapy (CIRT) in Patients with Pelvic Recurrence of Rectal Cancer"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-22"},"publish_date":"2008-10-22","publish_status":"0","recid":"69530","relation_version_is_last":true,"title":["L-[11C]methyl-methionine Positron Emission Tomography for Evaluation of Carbon Ion Radiotherapy (CIRT) in Patients with Pelvic Recurrence of Rectal Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:13:24.946997+00:00"}