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Analysis of free radical reactions in an aqueous sample caused by heavy-ion (carbon) beam irradiation
https://repo.qst.go.jp/records/69499
https://repo.qst.go.jp/records/694992ce9da46-2a54-4e79-b9b9-4fafb086514f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-06 | |||||
| タイトル | ||||||
| タイトル | Analysis of free radical reactions in an aqueous sample caused by heavy-ion (carbon) beam irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Kenichiro
× Matsumoto, Kenichiro× Nakanishi, Ikuo× Endo, Kazutoyo× Anzai, Kazunori× 松本 謙一郎× 中西 郁夫× 安西 和紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | High LET carbon ion beam cancer therapy using the Heavy-Ion Medical Accelerator in Chiba (HIMAC) (National Institute of Radiological Sciences, Chiba, Japan) began in 1994 [1]. The total number of patients who have undergone cancer therapy at HIMAC is now 4007 (at June 4, 2008) [2]. The expansion of heavy-ion cancer therapy is planned, and construction of a dissemination model (a small model) of the heavy-ion medical accelerator has begun at Gunma University [1]. Considering the popularity of the heavy-ion medical accelerator as a general medical instrument in the future, the quality and accuracy of heavy-ion cancer therapy must be improved and optimized. The oxygen effect is supposed to decrease by using higher LET irradiation such as heavy-ion beams, but cannot be eliminated completely. Hydroxyl radical generation by heavy-ion beam irradiation to an aqueous sample was reported. Increasing cell viability made by DMSO in a heavy-ion irradiated cultured cell sample was reported. Those facts suggest that the effect of heavy-ion beams can be modified by regulating redox reactions. Detection of oxygen free radical reactions and mapping its geometry in a large sample irradiated by a heavy-ion beam is thus important to regulate the oxygen effect of high LET irradiation. Therefore, a new method to detect free radical generation, which can be translated to an imaging technique, is required. In this presentation, the detection of free radical reactions in a gelatin sample irradiated by a heavy-ion beam was tested using EPR spectroscopic and MRI methods. The geometry of free radical generation and its LET dependence in the sample is discussed. \n[1] Tsujii H., Houshasen Kagaku [Radiol. Sci.] 50, 8–13 (2007). [2] Web-page of National Institute of Radiological Sciences, Topics, Released on Jul. 18, 2008. (http://www.nirs.go.jp/news/press/2008/07_18.shtml) |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Biomedical Redox Navigation (EPR2008: A Joint Conference of the 13th In Vivo ESR/EPR Spectroscopy & Imaging, the 10th International EPR Spin Trapping/Spin Labeling, and the 7th JSPS Core-to-Core Seminar) | |||||
| 発表年月日 | ||||||
| 日付 | 2008-09-30 | |||||
| 日付タイプ | Issued | |||||
