{"created":"2023-05-15T14:50:50.516458+00:00","id":69499,"links":{},"metadata":{"_buckets":{"deposit":"2d38dd8f-502d-4082-ae15-e257c6fa9d21"},"_deposit":{"created_by":1,"id":"69499","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69499"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069499","sets":["10:28"]},"author_link":["682021","682019","682017","682015","682020","682018","682016"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-09-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"High LET carbon ion beam cancer therapy using the Heavy-Ion Medical Accelerator in Chiba (HIMAC) (National Institute of Radiological Sciences, Chiba, Japan) began in 1994 [1]. The total number of patients who have undergone cancer therapy at HIMAC is now 4007 (at June 4, 2008) [2]. The expansion of heavy-ion cancer therapy is planned, and construction of a dissemination model (a small model) of the heavy-ion medical accelerator has begun at Gunma University [1]. Considering the popularity of the heavy-ion medical accelerator as a general medical instrument in the future, the quality and accuracy of heavy-ion cancer therapy must be improved and optimized.\nThe oxygen effect is supposed to decrease by using higher LET irradiation such as heavy-ion beams, but cannot be eliminated completely. Hydroxyl radical generation by heavy-ion beam irradiation to an aqueous sample was reported. Increasing cell viability made by DMSO in a heavy-ion irradiated cultured cell sample was reported. Those facts suggest that the effect of heavy-ion beams can be modified by regulating redox reactions. Detection of oxygen free radical reactions and mapping its geometry in a large sample irradiated by a heavy-ion beam is thus important to regulate the oxygen effect of high LET irradiation. Therefore, a new method to detect free radical generation, which can be translated to an imaging technique, is required. In this presentation, the detection of free radical reactions in a gelatin sample irradiated by a heavy-ion beam was tested using EPR spectroscopic and MRI methods. The geometry of free radical generation and its LET dependence in the sample is discussed.\n\\n[1] Tsujii H., Houshasen Kagaku [Radiol. Sci.] 50, 8–13 (2007).\n[2] Web-page of National Institute of Radiological Sciences, Topics, Released on Jul. 18, 2008. (http://www.nirs.go.jp/news/press/2008/07_18.shtml)","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Biomedical Redox Navigation (EPR2008: A Joint Conference of the 13th In Vivo ESR/EPR Spectroscopy & Imaging, the 10th International EPR Spin Trapping/Spin Labeling, and the 7th JSPS Core-to-Core Seminar)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Kenichiro"}],"nameIdentifiers":[{"nameIdentifier":"682015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"682016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Kazutoyo"}],"nameIdentifiers":[{"nameIdentifier":"682017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anzai, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"682018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"682021","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Analysis of free radical reactions in an aqueous sample caused by heavy-ion (carbon) beam irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of free radical reactions in an aqueous sample caused by heavy-ion (carbon) beam irradiation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-06"},"publish_date":"2008-10-06","publish_status":"0","recid":"69499","relation_version_is_last":true,"title":["Analysis of free radical reactions in an aqueous sample caused by heavy-ion (carbon) beam irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:13:46.960600+00:00"}