WEKO3
アイテム
Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer
https://repo.qst.go.jp/records/69492
https://repo.qst.go.jp/records/6949209d243d9-52d4-4b17-8273-7fef7c28b537
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-30 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamada, Shigeru
× Yamada, Shigeru× Yanagi, Takeshi× Hara, Ryusuke× Katou, Hirotoshi× Kamada, Tadashi× Tsujii, Hirohiko× 山田 滋× 柳 剛× 原 竜介× 加藤 博敏× 鎌田 正× 辻井 博彦 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose/Objective(s): To improve long-term local control and survival of locally recurrent rectal cancer, we have initiated a radiation dose-escalation trial using carbon ion beams. The purpose of this study is to evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients locally recurrent rectal cancer Materials/Methods: Between April 2001 and August 2007, 95 lesions at 90 patients were enrolled onto this study. Criteria for trial eligibility were confirmation of locally recurrent rectal cancers without distant metastases based on CT, MRI and PET findings and ECOG performance score 0,1,2. Contraindications for trial entry included pelvic bone destruction. Carbon beams of 290, 350 and 400 MeV/nucleon energy were generated in the HIMAC synchrotron. The dose was determined as 67.2GyE and escalated to 70.4GyE, 73.6GyE. Of the 90 eligible patients, 57 were male and 33 female. Median age was 62.5 years. The predominant sites of relapse were 41 presacral , 26 lymph nodes, 15 perineal and 8 anastomosis. Toxicities on organs were assessed according to the NCI-CTC classification. Tumor response was defined by the RESIST scoring system. Local recurrence was defined in terms of lesions occurring in the tumor bed. Survival curves were estimated by the Kaplan and Meier method. Results: Ten patients received radiation dose at 67.2GyE, 19(+1) at 70.4GyE and 63(+4) at 73.6GyE. All toxicities in the 95 lesions at 90 patients were relatively few and mild in these patients. No grade 3 to 5 acute toxicity was observed. The local control rates in 91 lesions are 89% at three year and 81% at five years. Local control rates at 3 year were 70% at 67.2GyE, 84% at 70.4GyE and 93% at 73.6GyE. In terms of symptomatic response within 3 months after treatment, pain improved in 97% of the symptomatic cases. Pain relief was maintained at one year in 67%, 91% and 100% of the patients treated with 67.2GyE, 70.4GyE and 73.6GyE, respectively. The three and five year overall survival rate in 90 patients were 60% and 43% respectively. Survival rates at 5 year were 24% at 67.2GyE, 32% at 70.4GyE and 57% at 73.6GyE. In the literature, the reported five-year survival rates for locally recurrent rectal cancer treated with resection were 20 to 40%. Conclusions: Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without acceptable morbidity. |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 50th Annual Meeting American Society for Therapeutic Radiology and Oncology | |||||
| 発表年月日 | ||||||
| 日付 | 2008-09-25 | |||||
| 日付タイプ | Issued | |||||
