{"created":"2023-05-15T14:50:50.213834+00:00","id":69492,"links":{},"metadata":{"_buckets":{"deposit":"cb064e28-4781-45f4-b0d6-8ce9d4a16736"},"_deposit":{"created_by":1,"id":"69492","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69492"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069492","sets":["10:28"]},"author_link":["681979","681980","681972","681971","681970","681978","681969","681977","681975","681974","681973","681976"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-09-25","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose/Objective(s): To improve long-term local control and\nsurvival of locally recurrent rectal cancer, we have initiated a radiation\ndose-escalation trial using carbon ion beams. The purpose of this study is\nto evaluate the tolerance for and effectiveness of carbon ion radiotherapy\nin patients locally recurrent rectal cancer\nMaterials/Methods: Between April 2001 and August 2007, 95 lesions at 90\npatients were enrolled onto this study. Criteria for trial eligibility were\nconfirmation of locally recurrent rectal cancers without distant metastases\nbased on CT, MRI and PET findings and ECOG performance score 0,1,2.\nContraindications for trial entry included pelvic bone destruction. Carbon\nbeams of 290, 350 and 400 MeV/nucleon energy were generated in the HIMAC\nsynchrotron. The dose was determined as 67.2GyE and escalated to 70.4GyE,\n73.6GyE. Of the 90 eligible patients, 57 were male and 33 female. Median age\nwas 62.5 years. The predominant sites of relapse were 41 presacral , 26\nlymph nodes, 15 perineal and 8 anastomosis. Toxicities on organs were\nassessed according to the NCI-CTC classification. Tumor response was defined\nby the RESIST scoring system. Local recurrence was defined in terms of\nlesions occurring in the tumor bed. Survival curves were estimated by the\nKaplan and Meier method.\nResults: Ten patients received radiation dose at 67.2GyE, 19(+1) at 70.4GyE\nand 63(+4) at 73.6GyE. All toxicities in the 95 lesions at 90 patients were\nrelatively few and mild in these patients. No grade 3 to 5 acute toxicity\nwas observed. The local control rates in 91 lesions are 89% at three year\nand 81% at five years. Local control rates at 3 year were 70% at 67.2GyE,\n84% at 70.4GyE and 93% at 73.6GyE. In terms of symptomatic response within 3\nmonths after treatment, pain improved in 97% of the symptomatic cases. Pain\nrelief was maintained at one year in 67%, 91% and 100% of the patients\ntreated with 67.2GyE, 70.4GyE and 73.6GyE, respectively. The three and five\nyear overall survival rate in 90 patients were 60% and 43% respectively.\nSurvival rates at 5 year were 24% at 67.2GyE, 32% at 70.4GyE and 57% at\n73.6GyE. In the literature, the reported five-year survival rates for\nlocally recurrent rectal cancer treated with resection were 20 to 40%.\nConclusions: Carbon ion radiotherapy seems to be a safe and effective\nmodality in the management of locally recurrent rectal cancer, providing\ngood local control and offering a survival advantage without acceptable\nmorbidity.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"50th Annual Meeting American Society for Therapeutic Radiology and Oncology","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"681969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanagi, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"681970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara, Ryusuke"}],"nameIdentifiers":[{"nameIdentifier":"681971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katou, Hirotoshi"}],"nameIdentifiers":[{"nameIdentifier":"681972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"681973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"681974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柳 剛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原 竜介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 博敏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681980","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-09-30"},"publish_date":"2008-09-30","publish_status":"0","recid":"69492","relation_version_is_last":true,"title":["Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:13:51.705083+00:00"}