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Expression and promoter methylation of Slc family genes in rat mammary carcinomas induced by different etiologies
https://repo.qst.go.jp/records/69476
https://repo.qst.go.jp/records/6947636503dc4-6def-4c85-a8a5-877222c12da3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-26 | |||||
| タイトル | ||||||
| タイトル | Expression and promoter methylation of Slc family genes in rat mammary carcinomas induced by different etiologies | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishimura, Mayumi
× Nishimura, Mayumi× Imaoka, Tatsuhiko× Kakinuma, Shizuko× Yamaguchi, Yu× Ohmachi, Yasushi× Yamashita, Satoshi× Ushijima, Toshikazu× Shimada, Yoshiya× 西村 まゆみ× 今岡 達彦× 柿沼 志津子× 山口 悠× 大町 康× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | An interesting target for metabolic tumor imaging and therapy is increased protein synthesis to which radiolabeled or boronated amino acids can be applied in cancer cells. Tumor cells require more amino acids for energy production and proliferation than normal tissue cells. Thus, an increased transport of amino acids can be characteristic for malignancy. However, the available data on the expression of amino acid transporters of Slc family for defined malignant cells are still insufficient. In the present study, we examined the status of expression of Slc family genes in rat mammary carcinomas developed by different etiologies including radiation (gamma-rays or carbon ions) and chemicals (MNU or PhIP) comparing with spontaneous ones. We found up-regulation of Slc7a1, 7a5(Lat1) and 16a13 and down-regulation of Slc1a5, 7a8(Lat2), 7a10, 28a2 and 28a3 in mammary carcinoma cells, suggesting an imbalance of transport of neutral amino acids, purine and pyrimidine. There was no etiology specific expression pattern. Decreased expression of Slc7a10 was found to be associated with hypermethylation of promoter region in chemically induced carcinomas. However, heavy-ion-induced ones were rarely methylated, suggesting an etiology dependent methylation. In conclusion, rat mammary carcinomas show similar expression pattern of amino acid transporters, which is independent of etiology. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 26th Congress of the International Association for Breast Cancer research | |||||
| 発表年月日 | ||||||
| 日付 | 2008-09-24 | |||||
| 日付タイプ | Issued | |||||
