@misc{oai:repo.qst.go.jp:00069476,
 author = {Nishimura, Mayumi and Imaoka, Tatsuhiko and Kakinuma, Shizuko and Yamaguchi, Yu and Ohmachi, Yasushi and Yamashita, Satoshi and Ushijima, Toshikazu and Shimada, Yoshiya and 西村 まゆみ and 今岡 達彦 and 柿沼 志津子 and 山口 悠 and 大町 康 and 島田 義也},
 month = {Sep},
 note = {An interesting target for metabolic tumor imaging and therapy is increased protein synthesis to which radiolabeled or boronated amino acids can be applied in cancer cells. Tumor cells require more amino acids for energy production and proliferation than normal tissue cells.  Thus, an increased transport of amino acids can be characteristic for malignancy.  However, the available data on the expression of amino acid transporters of Slc family for defined malignant cells are still insufficient.  In the present study, we examined the status of expression of Slc family genes in rat mammary carcinomas developed by different etiologies including radiation (gamma-rays or carbon ions) and chemicals (MNU or PhIP) comparing with spontaneous ones. 
We found up-regulation of Slc7a1, 7a5(Lat1) and 16a13 and down-regulation of Slc1a5, 7a8(Lat2), 7a10, 28a2 and 28a3 in mammary carcinoma cells, suggesting an imbalance of transport of neutral amino acids, purine and pyrimidine.  There was no etiology specific expression pattern.  Decreased expression of Slc7a10 was found to be associated with hypermethylation of promoter region in chemically induced carcinomas.  However, heavy-ion-induced ones were rarely methylated, suggesting an etiology dependent methylation.  In conclusion, rat mammary carcinomas show similar expression pattern of amino acid transporters, which is independent of etiology., The 26th Congress of the International Association for Breast Cancer research},
 title = {Expression and promoter methylation of Slc family genes in rat mammary carcinomas induced by different etiologies},
 year = {2008}
}