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Determination of starting time in Logan graphical analysis using the Runs test for quantitative PET imaging
https://repo.qst.go.jp/records/69463
https://repo.qst.go.jp/records/694637fd82cbd-b091-4997-839d-6f66a985b3d9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-22 | |||||
| タイトル | ||||||
| タイトル | Determination of starting time in Logan graphical analysis using the Runs test for quantitative PET imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kimura, Yuichi
× Kimura, Yuichi× Ohgaki, Hiroto× Naganawa, Mika× Shidahara, Miho× Sakata, Muneyuki× Ishiwata, Kiichi× Suga, Mikio× 木村 裕一× 長縄 美香× 志田原 美保× 坂田 宗之× 石渡 喜一× 菅 幹生 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Logan graphical analysis (LGA) is a widely used algorithm for PET quantitative imaging. In LGA, a total distribution volume (VT) is derived as a slope in the linear relation between both radiopharmaceutical concentrations in tissues and arterial plasma after the time, t*, when the radiopharmaceutical distributes uniformly in regional tissues, and therefore t* should be specified automatically for every voxels. This study proposes a new algorithm for t* determination, ratLGA, based on the runs test, which is a nonparametric hypothesis test for randomness. In ratLGA, LGA was applied to compute residuals for the line estimation with a set of feasible t* for PET studies. Then, the runs test was employed to decide the randomness of signs in the residuals with a significance level of 0.05. ratLGA is expected to be robust against the noise observed in voxel-based tTACs. Using t* (5 to 80 [min]), ratLGA was applied to the simulated and clinical data for 11C-SA4503, which is a ligand for the sigma1 receptors (Sakata, NeuroImage, 2007). In the simulation, VT was widely ranged from 10 to 60 [mL/cm3] considering the kinetics of SA4503, and the linear regressions for estimated VT were y=0.94x-1.23 in ratLGA and y=0.81x+3.80 when t* was fixed at 30 [min] (Sakata, 2007). The underestimation was improved by ratLGA. ratLGA increased a contrast in clinical VT images as shown in figures. Figures A and B were VT in case of ratLGA and the fixed t*, respectively, and Figure C showed the difference. In conclusion, the runs test is promising to determine t* for LGA. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2008 World Molecular Imaging Congress | |||||
| 発表年月日 | ||||||
| 日付 | 2008-09-13 | |||||
| 日付タイプ | Issued | |||||
