{"created":"2023-05-15T14:50:48.968213+00:00","id":69463,"links":{},"metadata":{"_buckets":{"deposit":"e7f29ce8-caf6-452b-9a2d-9920585e5df4"},"_deposit":{"created_by":1,"id":"69463","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69463"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069463","sets":["10:28"]},"author_link":["681712","681713","681715","681710","681707","681708","681716","681705","681704","681706","681709","681711","681714"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-09-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Logan graphical analysis (LGA) is a widely used algorithm for PET quantitative\nimaging. In LGA, a total distribution volume (VT) is derived as a slope in the linear relation\nbetween both radiopharmaceutical concentrations in tissues and arterial plasma after the time, t*,\nwhen the radiopharmaceutical distributes uniformly in regional tissues, and therefore t* should be\nspecified automatically for every voxels. This study proposes a new algorithm for t*\ndetermination, ratLGA, based on the runs test, which is a nonparametric hypothesis test for\nrandomness. In ratLGA, LGA was applied to compute residuals for the line estimation with a set\nof feasible t* for PET studies. Then, the runs test was employed to decide the randomness of signs\nin the residuals with a significance level of 0.05. ratLGA is expected to be robust against the noise\nobserved in voxel-based tTACs. Using t* (5 to 80 [min]), ratLGA was applied to the simulated and\nclinical data for 11C-SA4503, which is a ligand for the sigma1 receptors (Sakata, NeuroImage,\n2007). In the simulation, VT was widely ranged from 10 to 60 [mL/cm3] considering the kinetics of\nSA4503, and the linear regressions for estimated VT were y=0.94x-1.23 in ratLGA and\ny=0.81x+3.80 when t* was fixed at 30 [min] (Sakata, 2007). The underestimation was improved by\nratLGA. ratLGA increased a contrast in clinical VT images as shown in figures. Figures A and B\nwere VT in case of ratLGA and the fixed t*, respectively, and Figure C showed the difference. In\nconclusion, the runs test is promising to determine t* for LGA.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"2008 World Molecular Imaging Congress","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kimura, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"681704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohgaki, Hiroto"}],"nameIdentifiers":[{"nameIdentifier":"681705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naganawa, Mika"}],"nameIdentifiers":[{"nameIdentifier":"681706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shidahara, Miho"}],"nameIdentifiers":[{"nameIdentifier":"681707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakata, Muneyuki"}],"nameIdentifiers":[{"nameIdentifier":"681708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiwata, Kiichi"}],"nameIdentifiers":[{"nameIdentifier":"681709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suga, Mikio"}],"nameIdentifiers":[{"nameIdentifier":"681710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長縄 美香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原 美保","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂田 宗之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石渡 喜一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅 幹生","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681716","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Determination of starting time in Logan graphical analysis using the Runs test for quantitative PET imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Determination of starting time in Logan graphical analysis using the Runs test for quantitative PET imaging"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-09-22"},"publish_date":"2008-09-22","publish_status":"0","recid":"69463","relation_version_is_last":true,"title":["Determination of starting time in Logan graphical analysis using the Runs test for quantitative PET imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:14:11.511475+00:00"}