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Regional differences in occupancy of dopamine D2 receptors by second-generation antipsychotics in humans measured using PET
https://repo.qst.go.jp/records/69409
https://repo.qst.go.jp/records/69409625cc741-93cd-4dee-8303-9710f1395e34
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-07-22 | |||||
| タイトル | ||||||
| タイトル | Regional differences in occupancy of dopamine D2 receptors by second-generation antipsychotics in humans measured using PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ito, Hiroshi
× Ito, Hiroshi× Arakawa, Ryosuke× Takahashi, Hidehiko× Takano, Harumasa× Okumura, Masaki× Otsuka, Tatsui× Shidahara, Miho× Suhara, Tetsuya× 伊藤 浩× 荒川 亮介× 高橋 英彦× 高野 晴成× 奥村 正紀× 大塚 達以× 志田原 美保× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effects of antipsychotic drug have widely been considered to be mediated by blockade of dopamine D2 receptors. This hypothesis has been supported by positron emission tomography (PET) studies to determine occupancy of dopamine D2 receptors in patients with schizophrenia treated by antipsychotics [1]. The concept of limbic and cortical selectivity of second-generation antipsychotics, that is higher occupancy of dopamine D2 receptors in the cerebral cortices than in the striatum, has been suggested to explain those clinical efficacy with few extrapyramidal side effects [2]. In the present study, to elucidate the limbic and cortical selectivity of second-generation antipsychotics, regional distribution of occupancy of dopamine D2 receptors by risperidone was determined. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neuroreceptor Mapping 2008 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-07-19 | |||||
| 日付タイプ | Issued | |||||
