@misc{oai:repo.qst.go.jp:00069409,
 author = {Ito, Hiroshi and Arakawa, Ryosuke and Takahashi, Hidehiko and Takano, Harumasa and Okumura, Masaki and Otsuka, Tatsui and Shidahara, Miho and Suhara, Tetsuya and 伊藤 浩 and 荒川 亮介 and 高橋 英彦 and 高野 晴成 and 奥村 正紀 and 大塚 達以 and 志田原 美保 and 須原 哲也},
 month = {Jul},
 note = {Effects of antipsychotic drug have widely been considered to be mediated by blockade of dopamine D2 receptors. This hypothesis has been supported by positron emission tomography (PET) studies to determine occupancy of dopamine D2 receptors in patients with schizophrenia treated by antipsychotics [1]. The concept of limbic and cortical selectivity of second-generation antipsychotics, that is higher occupancy of dopamine D2 receptors in the cerebral cortices than in the striatum, has been suggested to explain those clinical efficacy with few extrapyramidal side effects [2]. In the present study, to elucidate the limbic and cortical selectivity of second-generation antipsychotics, regional distribution of occupancy of dopamine D2 receptors by risperidone was determined., Neuroreceptor Mapping 2008},
 title = {Regional differences in occupancy of dopamine D2 receptors by second-generation antipsychotics in humans measured using PET},
 year = {2008}
}