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A new graphic plot method for determination of neuroreceptor binding in PET studies
https://repo.qst.go.jp/records/69408
https://repo.qst.go.jp/records/694080c77d61e-3ac6-4481-871b-436ea04d2da2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-07-22 | |||||
| タイトル | ||||||
| タイトル | A new graphic plot method for determination of neuroreceptor binding in PET studies | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ito, Hiroshi
× Ito, Hiroshi× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In positron emission tomography (PET) studies with radioligands for neuroreceptors, the kinetics of tracers has been described by the standard two-tissue compartment model which includes compartments of nondisplaceable binding and specific binding to receptors. Previously, we have developed a graphic plot method to determine the influx rate constant (K1) and distribution volume for tracers which show kinetics according to the one-tissue compartment model [1]. In this plot, Y(t) is the ratio of brain tissue activity (CT) to time-integrated arterial input function (CP), and X(t) is the ratio of time-integrated brain tissue activity to time-integrated arterial input function. The y-intercept of linear regression of plots represents the K1, and x-intercept represents the distribution volume. In the present study, we have applied this graphic plot method to PET data of [C-11]FLB457 which is a radioligand for extrastriatal dopamine D2 receptors in order to determine the nondisplaceable and specific binding. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neuroreceptor Mapping 2008 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-07-19 | |||||
| 日付タイプ | Issued | |||||
