{"created":"2023-05-15T14:50:46.576931+00:00","id":69408,"links":{},"metadata":{"_buckets":{"deposit":"f8f63ad0-46ad-476c-967f-80a8c0e78d1e"},"_deposit":{"created_by":1,"id":"69408","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69408"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069408","sets":["10:28"]},"author_link":["681154","681153"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-07-19","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In positron emission tomography (PET) studies with radioligands for neuroreceptors, the kinetics of tracers has been described by the standard two-tissue compartment model which includes compartments of nondisplaceable binding and specific binding to receptors. Previously, we have developed a graphic plot method to determine the influx rate constant (K1) and distribution volume for tracers which show kinetics according to the one-tissue compartment model [1]. In this plot, Y(t) is the ratio of brain tissue activity (CT) to time-integrated arterial input function (CP), and X(t) is the ratio of time-integrated brain tissue activity to time-integrated arterial input function. The y-intercept of linear regression of plots represents the K1, and x-intercept represents the distribution volume. In the present study, we have applied this graphic plot method to PET data of [C-11]FLB457 which is a radioligand for extrastriatal dopamine D2 receptors in order to determine the nondisplaceable and specific binding.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Neuroreceptor Mapping 2008","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"681153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681154","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"A new graphic plot method for determination of neuroreceptor binding in PET studies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A new graphic plot method for determination of neuroreceptor binding in PET studies"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-07-22"},"publish_date":"2008-07-22","publish_status":"0","recid":"69408","relation_version_is_last":true,"title":["A new graphic plot method for determination of neuroreceptor binding in PET studies"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:14:51.142544+00:00"}