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Analysis of gene expression profiles in mice exposed to low-dose rate radiation.
https://repo.qst.go.jp/records/69051
https://repo.qst.go.jp/records/6905108d95aad-2dfb-442d-a68c-0ca5f8d38067
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-23 | |||||
| タイトル | ||||||
| タイトル | Analysis of gene expression profiles in mice exposed to low-dose rate radiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Taki, Keiko
× Taki, Keiko× Bing, Wang× Nakajima, Tetsuo× K, Go× Ono, Tetsuya× Matsumoto, Tsuneya× Oghiso, Yoichi× Tanaka, Kimio× Ichinohe, Kazuaki× Nakamura, Shingo× Tanaka, Satoshi× Nenoi, Mitsuru× 瀧 景子× 王 冰× 中島 徹夫× 呉 健羽× 小野 哲也× 松本 恒弥× 小木曽 洋一× 田中 公夫× 一戸 一晃× 中村 慎吾× 田中 聡× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Risk assessment of low-dose rate radiation is an important issue. Tanaka et. al. have previously reported the late effects of chronic exposure to low-dose rate gamma rays as assayed by life span using 4000 mice (Rad. Res. (2003)160, 376-379). Statistical analyses showed that the life spans of mice of both sexes irradiated with 16uGy/min(P < 0.0001) and of females irradiated with 830nGy/min(P < 0.05) were significantly shorter than those of the control group. In this study, we investigate the molecular mechanisms of this shortening of life span under continuous low-dose rate irradiation in mice. We followed experimental conditions of Tanaka et. al. C57BL/6J mice were exposed to gamma rays at the low-dose rates of 32nGy/min (21mGy), 650nGy/min (420mGy), 13uGy/min (8.0Gy) continuously. RNA was extracted from kidney of irradiated or on-irradiated mice, and gene expression profiles were determined using Illumina Sentric Mouse-6 microarrays. The 54 genes have been extracted with a difference in expression by 1.6 times or more after irradiation. The pathway analysis was done for the gene of each 54. In the irradiated groups at 650 nGy/min (total dose 420 mGy) and 13 uGy/min (total dose 8 Gy), 4 genes categorized to the mitochondrial oxidative phosphorylation pathway were activated. These results strongly suggest one possibility that the reactive oxygen produced by activated mitochondrial oxidative phosphorylation after continuous low-dose rate irradiation is a cause for the shortening of life span. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
