{"created":"2023-05-15T14:50:29.562030+00:00","id":69051,"links":{},"metadata":{"_buckets":{"deposit":"de614742-4c74-4af9-a022-4c61ee308933"},"_deposit":{"created_by":1,"id":"69051","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69051"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069051","sets":["10:28"]},"author_link":["677719","677729","677727","677718","677717","677711","677715","677716","677730","677720","677721","677723","677725","677732","677714","677726","677724","677709","677710","677712","677728","677722","677731","677713"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-07-12","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Risk assessment of low-dose rate radiation is an important issue.  Tanaka et. al. have previously reported the late effects of chronic exposure to low-dose rate gamma rays as assayed by life span using 4000 mice (Rad. Res. (2003)160, 376-379).  Statistical analyses showed that the life spans of mice of both sexes irradiated with 16uGy/min(P < 0.0001) and of females irradiated with 830nGy/min(P < 0.05) were significantly shorter than those of the control group.  \nIn this study, we investigate the molecular mechanisms of this shortening of life span under continuous low-dose rate irradiation in mice.  We followed experimental conditions of Tanaka et. al. C57BL/6J mice were exposed to gamma rays at the low-dose rates of 32nGy/min (21mGy), 650nGy/min (420mGy), 13uGy/min (8.0Gy) continuously.  RNA was extracted from kidney of irradiated or on-irradiated mice, and gene expression profiles were determined using Illumina Sentric Mouse-6 microarrays.  The 54 genes have been extracted with a difference in expression by 1.6 times or more after irradiation.  The pathway analysis was done for the gene of each 54. In the irradiated groups at 650 nGy/min (total dose 420 mGy) and 13 uGy/min (total dose 8 Gy), 4 genes categorized to the mitochondrial oxidative phosphorylation pathway were activated. These results strongly suggest one possibility that the reactive oxygen produced by activated mitochondrial oxidative phosphorylation after continuous low-dose rate irradiation is a cause for the shortening of life span.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"13th International Congress of Radiation Research","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Taki, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"677709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"677710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo"}],"nameIdentifiers":[{"nameIdentifier":"677711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"K, Go"}],"nameIdentifiers":[{"nameIdentifier":"677712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"677713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Tsuneya"}],"nameIdentifiers":[{"nameIdentifier":"677714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oghiso, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"677715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kimio"}],"nameIdentifiers":[{"nameIdentifier":"677716","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichinohe, Kazuaki"}],"nameIdentifiers":[{"nameIdentifier":"677717","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"677718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"677719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"677720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"瀧 景子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 徹夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"呉 健羽","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 恒弥","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小木曽 洋一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 公夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"一戸 一晃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 慎吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 聡","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677731","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"677732","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Analysis of gene expression profiles in mice exposed to low-dose rate radiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of gene expression profiles in mice exposed to low-dose rate radiation."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-07-23"},"publish_date":"2007-07-23","publish_status":"0","recid":"69051","relation_version_is_last":true,"title":["Analysis of gene expression profiles in mice exposed to low-dose rate radiation."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:19:04.186874+00:00"}