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アイテム
Distinct glial responses to diverse chemical neurotoxicants in the striatum as monitored by imaging agents
https://repo.qst.go.jp/records/68886
https://repo.qst.go.jp/records/6888675d4f3a6-44c3-4327-af0f-fa5117fce3e7
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-03-26 | |||||
| タイトル | ||||||
| タイトル | Distinct glial responses to diverse chemical neurotoxicants in the striatum as monitored by imaging agents | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ki, Hin
× Ki, Hin× Higuchi, Makoto× Maeda, Jun× Inaji, Motoki× Okauchi, Takashi× Zhang, Ming-Rong× Suzuki, Kazutoshi× Andou, Kiyoshi× Suhara, Tetsuya× 季 斌× 樋口 真人× 前田 純× 稲次 基希× 岡内 隆× 張 明栄× 鈴木 和年× 安東 潔× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study was aimed at clarifying correlation between signature of gliosis and type of neuronal insult, by analyzing glial activation in neurotoxicant-induced neurodegeneration including methamphetamine (METH), 6-hydoxydomaine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), kainic acid (KA), and cuprizone. Analyses using tracers for in vivo imaging along with immunohistochemistry revealed that METH, 6-OHDA, and MPTP induced serious loss of dopaminergic terminals and pronounced astrogliosis in the striatum of mouse, rat, and marmoset, respectively, while morphology and number of microglia as well as levels of peripheral-type benzodiazepine receptor/recognition site (PBR) were not altered in the same regions. Cuprizone and KA induced a notable increase in PBR levels in the striatum, hippocampus, entorhinal cortex and striatum-nigra, and this alteration was colocalized with severe demyelination. Additional histopathological analyses illustrated a tight correlation of demyelination with significant microgliosis and increased PBR levels, while degeneration of dopaminergic neuron, which is know to project unmyelinated axons, was concomitant with notable astrogliosis and barely detectable microgliosis. These findings delineate two distinct triggers of glial activation, one inducing both astroglial and microglial responses in close association with demyelination and the other being exclusively accompanied with augmented astroglial activity. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第21回日本薬物動態学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2006-12-01 | |||||
| 日付タイプ | Issued | |||||
