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Carbon-ion Therapy For Patients With Locally Recurrent Rectal Cancer
https://repo.qst.go.jp/records/68777
https://repo.qst.go.jp/records/6877766c0498d-f0f2-4d55-bb6b-6e8724d0f22b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-11-17 | |||||
| タイトル | ||||||
| タイトル | Carbon-ion Therapy For Patients With Locally Recurrent Rectal Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamada, Shigeru
× Yamada, Shigeru× 山田 滋 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | <B>Purpose/Objective(s): To improve long-term local control and survival of locally recurrent rectal cancer, we have initiated a radiation dose-escalation trial using carbon ion beams. The purpose of this study is to evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients locally recurrent rectal cancer </b><br> <B>Materials/Methods: Between April 2001 and February 2006, 70 lesions at 65 patients were enrolled onto this study. Criteria for trial eligibility were confirmation of locally recurrent rectal cancers without distant metastases based on CT, MRI and PET findings and ECOG performance score 0,1,2. Contraindications for trial entry included pelvic bone destruction or infiltration into the bladder. Carbon beams of 290, 350 and 400 MeV/nucleon energy were generated in the HIMAC synchrotron. The dose was determined as 67.2GyE and escalated to 70.4GyE,73.6GyE. Of the 65 eligible patients, 42 were male and 23 female. Median age was 62.5 years. The predominant sites of relapse were 26 presacral , 17 lymph nodes, 16 perineal and 8 anastomosis. Toxicities on organs were assessed according to the NCI-CTC and RTOG/EOTRC classification. Tumor response was defined by the RESIST scoring system. Local recurrence was defined in terms of lesions occurring in the tumor bed. Survival curves were estimated by the Kaplan and Meier method.</b><br> <B>Results: Ten patients received radiation dose at 67.2GyE, 17(+1) at 70.4GyE and 38(+4) at 73.6GyE. All toxicities in the 70 lesions at 65 patients were relatively few and mild in these patients. No grade 3 to 5 acute and late toxicity was observed. Tumor response was evaluated in 69 lesions patients. CR was observed in 10 lesions and PR in 16. The local control rates in 69 lesions are 93% at one year and 83% at two years. Local control rates at one year were 80% at 67.2GyE, 86% at 70.4GyE and 100% at 73.6GyE. In terms of symptomatic response within 3 months after treatment, pain improved in 97% of the symptomatic cases. Pain relief was maintained at one year in 67%, 91% and 100% of the patients treated with 67.2GyE ,, 70.4GyE and 73.6GyE, respectively. The one and two year overall survival rate were 91% and 75% respectively. In the literature, the reported two-year survival rates for locally recurrent rectal cancer treated with radiation were 20 to 40%.</b><br> <B>Conclusions: Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without acceptable morbidity. </b><br> |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 米国治療放射線腫瘍学会 ASTRO48 | |||||
| 発表年月日 | ||||||
| 日付 | 2006-11-09 | |||||
| 日付タイプ | Issued | |||||
