{"_buckets": {"deposit": "25439111-e73a-4abb-a789-b4def71b148a"}, "_deposit": {"created_by": 1, "id": "68571", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "68571"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00068571", "sets": ["28"]}, "author_link": ["673001", "672996", "672999", "673012", "673006", "673010", "673000", "673007", "672994", "672992", "673008", "673005", "673002", "672997", "673003", "673004", "673009", "673011", "672995", "672993", "672998"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2004-11-06", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "アルツハイマー型痴呆（ＡＤ）治療薬であるアセチルコリンエステラーゼ（ＡＣｈＥ）阻害剤、塩酸ドネペジルは、現在ＡＤ患者において広く用いられており、また新規のＡＤｈＣ阻害剤の開発進んでいる。そこで我々は、ＡＣｈ類似体〔11Ｃ〕ＭＰ4Ａを用い、ドネペジル静脈内単回投与におけるサルＰＥＴスキャンプロトコールの確立を目的とした。６頭のアカゲサルにドネペジルを２用量（１００，２５０ｕｇ／ｋｇ）それぞれ３週間の間隔をあけて、静脈内投与し、同時に６０分スキャン施行、脳内ＡＣｈＥ阻害率を推定した。また、投与後１４分、７６分血漿中濃度測定用の採血を行い、ＬＣ／ＭＳ／ＭＳにて分析した。ドネペジル血漿中濃度と脳内ＡＣｈＥ阻害率から推定したサルＩＣ５０は、１２症例のＡＤ患者のＩＣ５０と近接した結果が得られた。以上より、静脈内単回投与におけるサルＰＥＴスキャンプロトコールは確立したと考えられ、今後薬剤間の脳内ＡＣｈＥ阻害率の比較や新規のＡＣｈＥ阻害剤の用量決定等に応用されることが期待される。", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要（会議名, 開催地, 会期, 主催者等）", "attribute_value_mlt": [{"subitem_description": "第44回日本核医学会総会", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "白石, 哲也"}], "nameIdentifiers": [{"nameIdentifier": "672992", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "福士, 清"}], "nameIdentifiers": [{"nameIdentifier": "672993", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "篠遠, 仁"}], "nameIdentifiers": [{"nameIdentifier": "672994", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田中, 典子"}], "nameIdentifiers": [{"nameIdentifier": "672995", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "黄田, 常嘉"}], "nameIdentifiers": [{"nameIdentifier": "672996", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐藤, 康一"}], "nameIdentifiers": [{"nameIdentifier": "672997", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平野, 成樹"}], "nameIdentifiers": [{"nameIdentifier": "672998", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "棚田, 修二"}], "nameIdentifiers": [{"nameIdentifier": "672999", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊豫, 雅臣"}], "nameIdentifiers": [{"nameIdentifier": "673000", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "菊池, 達矢"}], "nameIdentifiers": [{"nameIdentifier": "673001", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "入江, 俊章"}], "nameIdentifiers": [{"nameIdentifier": "673002", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "白石 哲也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "673003", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "福士 清", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "673004", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "篠遠 仁", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "673005", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田中 典子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "673006", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "黄田 常嘉", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "673007", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐藤 康一", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "673008", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平野 成樹", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "673009", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "棚田 修二", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "673010", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "菊池 達矢", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "673011", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "入江 俊章", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "673012", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "サル脳ＰＥＴにおけるアセチルコリンエステラーゼ阻害剤の評価系の確立", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "サル脳ＰＥＴにおけるアセチルコリンエステラーゼ阻害剤の評価系の確立"}]}, "item_type_id": "10005", "owner": "1", "path": ["28"], "permalink_uri": "https://repo.qst.go.jp/records/68571", "pubdate": {"attribute_name": "公開日", "attribute_value": "2006-07-04"}, "publish_date": "2006-07-04", "publish_status": "0", "recid": "68571", "relation": {}, "relation_version_is_last": true, "title": ["サル脳ＰＥＴにおけるアセチルコリンエステラーゼ阻害剤の評価系の確立"], "weko_shared_id": -1}