{"created":"2023-05-15T14:50:08.372265+00:00","id":68571,"links":{},"metadata":{"_buckets":{"deposit":"25439111-e73a-4abb-a789-b4def71b148a"},"_deposit":{"created_by":1,"id":"68571","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68571"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068571","sets":["10:28"]},"author_link":["673001","672996","672999","673012","673006","673010","673000","673007","672994","672992","673008","673005","673002","672997","673003","673004","673009","673011","672995","672993","672998"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アルツハイマー型痴呆（ＡＤ）治療薬であるアセチルコリンエステラーゼ（ＡＣｈＥ）阻害剤、塩酸ドネペジルは、現在ＡＤ患者において広く用いられており、また新規のＡＤｈＣ阻害剤の開発進んでいる。そこで我々は、ＡＣｈ類似体〔11Ｃ〕ＭＰ4Ａを用い、ドネペジル静脈内単回投与におけるサルＰＥＴスキャンプロトコールの確立を目的とした。６頭のアカゲサルにドネペジルを２用量（１００，２５０ｕｇ／ｋｇ）それぞれ３週間の間隔をあけて、静脈内投与し、同時に６０分スキャン施行、脳内ＡＣｈＥ阻害率を推定した。また、投与後１４分、７６分血漿中濃度測定用の採血を行い、ＬＣ／ＭＳ／ＭＳにて分析した。ドネペジル血漿中濃度と脳内ＡＣｈＥ阻害率から推定したサルＩＣ５０は、１２症例のＡＤ患者のＩＣ５０と近接した結果が得られた。以上より、静脈内単回投与におけるサルＰＥＴスキャンプロトコールは確立したと考えられ、今後薬剤間の脳内ＡＣｈＥ阻害率の比較や新規のＡＣｈＥ阻害剤の用量決定等に応用されることが期待される。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第44回日本核医学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白石, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"672992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 清"}],"nameIdentifiers":[{"nameIdentifier":"672993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"672994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 典子"}],"nameIdentifiers":[{"nameIdentifier":"672995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黄田, 常嘉"}],"nameIdentifiers":[{"nameIdentifier":"672996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 康一"}],"nameIdentifiers":[{"nameIdentifier":"672997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"672998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田, 修二"}],"nameIdentifiers":[{"nameIdentifier":"672999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊豫, 雅臣"}],"nameIdentifiers":[{"nameIdentifier":"673000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池, 達矢"}],"nameIdentifiers":[{"nameIdentifier":"673001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"673002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白石 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 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修二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"673012","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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