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Combined effects of X-rays and N-ethyl-N-nitrosourea on carcinogenesis and life-span-shortening in B6C3F1 mice
https://repo.qst.go.jp/records/68245
https://repo.qst.go.jp/records/68245fd88bf24-e26e-4615-9eb7-85e87f95e866
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-11-19 | |||||
| タイトル | ||||||
| タイトル | Combined effects of X-rays and N-ethyl-N-nitrosourea on carcinogenesis and life-span-shortening in B6C3F1 mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kakinuma, Shizuko
× Kakinuma, Shizuko× Amasaki, Yoshiko× Yamauchi, Kazumi× Nishimura, Mayumi× Imaoka, Tatsuhiko× Shimada, Yoshiya× 柿沼 志津子× 甘崎 佳子× 山内 一己× 西村 まゆみ× 今岡 達彦× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation carcinogenesis in human is considered as a result of the combined effect of radiation and environment factors. We previously showed that smaller doses of X-rays reduced the incidence of TL induced by N-ethyl-N-nitrosourea (ENU), while large doses of X-rays increased and accelerated the TL development in a synergistic manner. This indicates the mode of combined effect is dependent upon the dose of X-rays. In this study, we aimed to determine the mode of combined effect on tumors other than TL and life-span (LS) shortening. B6C3F1 mice (4-week-old female) were irradiated with X-rays (0.2 - 2.0 Gy a week x 4 times) or treated with ENU for 4weeks (50 - 400 ppm in drinking water) from 8-week-old. For combined treatment, the mice were irradiated with X-rays (0.2 - 1.0 Gy a week x 4 times) and then treated with ENU (50 - 200 ppm). The LS after combined exposure (0.2/0.4 Gy X-rays with 200 ppm ENU) was much longer than that of ENU treatment alone, suggesting small dose of X-rays has antagonistic function. Contrary to the results of TL, incidence of tumors of lung, liver and ovaries increased more than additively after the combination of ENU with X-rays even at small doses. Thus, the role of X-rays in combined exposure was dependent not only the dose used but also the tissues examined. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第48回日本放射線影響学会／第1回アジア放射線研究会議 | |||||
| 発表年月日 | ||||||
| 日付 | 2005-11-17 | |||||
| 日付タイプ | Issued | |||||
