{"created":"2023-05-15T14:49:50.917152+00:00","id":68245,"links":{},"metadata":{"_buckets":{"deposit":"13392139-9509-4c78-8429-1a6e2198b15b"},"_deposit":{"created_by":1,"id":"68245","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"68245"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00068245","sets":["10:28"]},"author_link":["670028","670020","670024","670019","670023","670025","670029","670022","670021","670026","670027","670018"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2005-11-17","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Radiation carcinogenesis in human is considered as a result of the combined effect of radiation and environment factors. We previously showed that smaller doses of X-rays reduced the incidence of TL induced by N-ethyl-N-nitrosourea (ENU), while large doses of X-rays increased and accelerated the TL development in a synergistic manner. This indicates the mode of combined effect is dependent upon the dose of X-rays. In this study, we aimed to determine the mode of combined effect on tumors other than TL and life-span (LS) shortening.\nB6C3F1 mice (4-week-old female) were irradiated with X-rays (0.2 - 2.0 Gy a week x 4 times) or treated with ENU for 4weeks (50 - 400 ppm in drinking water) from 8-week-old. For combined treatment, the mice were irradiated with X-rays (0.2 - 1.0 Gy a week x 4 times) and then treated with ENU (50 - 200 ppm).\nThe LS after combined exposure (0.2/0.4 Gy X-rays with 200 ppm ENU) was much longer than that of ENU treatment alone, suggesting small dose of X-rays has antagonistic function. Contrary to the results of TL, incidence of tumors of lung, liver and ovaries increased more than additively after the combination of ENU with X-rays even at small doses. Thus, the role of X-rays in combined exposure was dependent not only the dose used but also the tissues examined.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第48回日本放射線影響学会／第1回アジア放射線研究会議","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"670018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Amasaki, Yoshiko"}],"nameIdentifiers":[{"nameIdentifier":"670019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamauchi, Kazumi"}],"nameIdentifiers":[{"nameIdentifier":"670020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"670021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imaoka, Tatsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"670022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"670023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"670024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甘崎 佳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"670025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山内 一己","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"670026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"670027","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"670028","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"670029","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Combined effects of X-rays and N-ethyl-N-nitrosourea on carcinogenesis and life-span-shortening in B6C3F1 mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Combined effects of X-rays and N-ethyl-N-nitrosourea on carcinogenesis and life-span-shortening in B6C3F1 mice"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-11-19"},"publish_date":"2005-11-19","publish_status":"0","recid":"68245","relation_version_is_last":true,"title":["Combined effects of X-rays and N-ethyl-N-nitrosourea on carcinogenesis and life-span-shortening in B6C3F1 mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:28:23.898563+00:00"}