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Combined effects of X-rays and N-ethyl-N-nitrosourea in murine thymic lymphoma s -(2) Analysis in Ikaros point mutation-

https://repo.qst.go.jp/records/68243
https://repo.qst.go.jp/records/68243
dc018c2e-7399-4492-adb6-85bc276ca0a7
Item type 会議発表用資料 / Presentation(1)
公開日 2005-11-19
タイトル
タイトル Combined effects of X-rays and N-ethyl-N-nitrosourea in murine thymic lymphoma s -(2) Analysis in Ikaros point mutation-
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Amasaki, Yoshiko

× Amasaki, Yoshiko

WEKO 669995

Amasaki, Yoshiko

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Kakinuma, Shizuko

× Kakinuma, Shizuko

WEKO 669996

Kakinuma, Shizuko

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Yamauchi, Kazumi

× Yamauchi, Kazumi

WEKO 669997

Yamauchi, Kazumi

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Nishimura, Mayumi

× Nishimura, Mayumi

WEKO 669998

Nishimura, Mayumi

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Imaoka, Tatsuhiko

× Imaoka, Tatsuhiko

WEKO 669999

Imaoka, Tatsuhiko

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Shimada, Yoshiya

× Shimada, Yoshiya

WEKO 670000

Shimada, Yoshiya

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甘崎 佳子

× 甘崎 佳子

WEKO 670001

en 甘崎 佳子

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柿沼 志津子

× 柿沼 志津子

WEKO 670002

en 柿沼 志津子

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山内 一己

× 山内 一己

WEKO 670003

en 山内 一己

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西村 まゆみ

× 西村 まゆみ

WEKO 670004

en 西村 まゆみ

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今岡 達彦

× 今岡 達彦

WEKO 670005

en 今岡 達彦

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島田 義也

× 島田 義也

WEKO 670006

en 島田 義也

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抄録
内容記述タイプ Abstract
内容記述 Ikaros is a potent tumor suppressor gene in both human and murine leukemogenesis. We previously showed Ikaros alteration type is differed between X-ray-induced murine thymic lymphoma (TL) and N-ethyl-N-nitrosourea (ENU) -induced TL. Thus, X-ray-induced TL was characterized by altered splicing, null expression and point mutations, which were accompanied by by loss of heterozygosity (LOH). ENU-induced TL harbored only point mutation without LOH. We showed that combined treatment of X-rays (0.8-1.0 Gy x 4 times) and ENU (100, 200ppm) synergistically increased TL incidence. The aim of the curresnt study is to elucidate the underlying mechanism in the lymphomagenesis induced by combined treatment of X-rays and ENU. In this study, we analyzed the mutation status of Ikaros in the TLs induced by combined (X-rays following ENU) treatment.
B6C3F1 mice (4-week-old female) were irradiated by X-rays (0.2 - 1.0 Gy a week x 4 times) and then treated by EMU (50 - 200 ppm in drinking water) from 8-week-old. The analyses of LOH on chromosome 11, expression by RT-PCR and western blotting, and mutation by sequence were performed.
Ikaros splicing and null expression was observed in X-ray-induced TL was 10 and12%, ENU-induced TL was both 0%, combined-induced TL was 6 and 0%. Point mutation and LOH status were 26%(LOH:73%) in X-ray-induced TL 26%(LOH:0%) in ENU-induced TL. In combined-induced TL, that was increased to 40% (LOH: 20%), it is ENU type. Thus, X-rays plays a promoter for ENU-induced leukemogenesis in the TL induced by X-rays following ENU.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 第48回日本放射線影響学会/第1回アジア放射線研究会議
発表年月日
日付 2005-11-17
日付タイプ Issued
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