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Effects of DTPP, CAP, LIHOPO and DTPA on Removal of Plutonium in Rats
https://repo.qst.go.jp/records/67836
https://repo.qst.go.jp/records/678360259e9f1-c079-4475-8726-07b9b79deee0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-07-20 | |||||
| タイトル | ||||||
| タイトル | Effects of DTPP, CAP, LIHOPO and DTPA on Removal of Plutonium in Rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukuda, Satoshi
× Fukuda, Satoshi× Iida, Haruzo× Burgada, Ramon× Bailly, Theodorine× 福田 俊× 飯田 治三 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effects of new two chelating agents, DTPP and CAP, in removing plutonium were compared to those of 3,4,3-LIHOPO (LIHOPO) and Ca-DTPA in rats. Twenty five female Wistar rats, 8 weeks old, were pre-injected with plutonium-239 in the right femoral muscles and divided into five groups; thereafter Rats of four groups were injected intraperitoneally with 30 mmol/kg of DTPP, CAP, LIHOPO or Ca-DTPA respectively, once per day for 3 days, beginning 1 hr after plutonium injection on the first day. The other one group was used a control. On day 4, rats were sacrificed to obtain organs and serum. Urinary excretion rate of DTPP was higher, and followed by Ca-DTPA, LIHOPO at the first day and decreased. Feces excretion rate of LIHOPO was higher than other agents for 3 days. CAP had no effect. Total amount of excreted Pu in urine and feces for 3 days of LIHOPO was higher, and followed by Ca-DTPA and DTPP. In the concentration of organs and serum were LIHOPO=DTPP<Ca-DTPA in bone and liver, DTPP<LIHOPO=Ca-DTPA in kidney, DTPP=LIHOPO in serum. The results indicate that LIHOPO was most effective in removing plutonium and DTPP may be worthwhile to examine more in future. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 7th International Symposium on Chelating Agents in Biomedicine, Toxicology and therapeutics | |||||
| 発表年月日 | ||||||
| 日付 | 2004-07-11 | |||||
| 日付タイプ | Issued | |||||
