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低線量重粒子線の細胞成長への影響
https://repo.qst.go.jp/records/67825
https://repo.qst.go.jp/records/678253c073ede-6bcf-42b6-93ce-60b5b302566e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-07-05 | |||||
| タイトル | ||||||
| タイトル | 低線量重粒子線の細胞成長への影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
斎藤, 志織
× 斎藤, 志織× 内堀, 幸夫× 鈴木, 雅雄× 岡安, 隆一× 斎藤 志織× 内堀 幸夫× 鈴木 雅雄× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We measured the growth rates of various primary human fibroblasts under very low levels of high LET particles. This was performed using an incubator and a radiation detector located in the HIMAC biology beam room. NHEJ deficient 180BR cells (Ligase IV mutant) showed an immediate growth delay after about 10 m Gy accumulated exposure (~6 days) while there is no clear delay in normal as well as ataxia telangiectasia (AT) cells for more than 50 days. 180 BR cells in the HIMAC incubator also showed an accelerated senescence. These phenomena indicate the involvement of NHEJ proteins in the cell growth control. In order to access damage caused by low levels of high LET radiation as well as low levels of X-irradiation, we have measured cell growth in normal human fibroblasts exposed to 0.1 Gy carbon particles (LET=80 keV/um) and 0.1 Gy X-rays. A clear early senescence like growth retardation was observed in irradiated cells sooner than in control cells without radiation. These results indicate that even a small amount of radiation may lead to a negative biological effect in human cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第46回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2003-10-08 | |||||
| 日付タイプ | Issued | |||||
