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A long-term treatment of chelating agents, Zn-DTPA and CBMIDA,reduces cancers and prevents shortening of life span in plutonium administered rats
https://repo.qst.go.jp/records/67792
https://repo.qst.go.jp/records/677922d093b77-5c38-4f57-87e1-a7c78919d62f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-05-31 | |||||
| タイトル | ||||||
| タイトル | A long-term treatment of chelating agents, Zn-DTPA and CBMIDA,reduces cancers and prevents shortening of life span in plutonium administered rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukuda, Satoshi
× Fukuda, Satoshi× Iida, Haruzo× Yan, Xueming× Xie, Yuyuan× 福田 俊× 飯田 治三× 厳 雪銘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of long-term administration of Zn-DTPA (diethyene-triamine-penta-actic acid) and CBMIDA [Catechol-3,6-bis(methyleiminodiaetic acid)] on plutonium-induced bone tumors and shortening of life span in rats were examined. One-hundred-twenty female rats were injected with doses of 18.5, 37, and 370 kBq/kg of plutonium-239. A daily intrperitoneally injected dose of 30 mmol/kg Ca-DTPA was administered to each of 40 rats of the 18.5, 37, and 370 kBq/kg of plutonium groups for first three days followed by the same dose of Zn-DTPA in orally administered in dinking water, while another 40 rats injected with 37 kBq/kg of plutonium were injected intraperitoneally with 30 mmol/kg CBMIDA for the first three days followed by oral administration. High urinary excretion of plutonium was observed for 14-21 days after plutonium injection in the chelating agent-treated groups. In the Zn-DTPA and CBMIDA treated groups, the mean life spans were significantly more prolonged compared with each corresponding (plutonium-injected) group. The incidences of bone tumors in the Zn-DTPA groups were reduced to zero from 10% in the 18.5 and 37 kBq/kg plutonium groups, while they increased to 10% from zero in the 370 kBq/kg plutonium group. The results indicated that human doses of Zn-DTPA and CBMIDA were effective in reducing plutonium-induced effects such as the shortening of life span and the induction of bone tumors in rats. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 11th International Congress of the International Radiation Protection Association | |||||
| 発表年月日 | ||||||
| 日付 | 2004-05-28 | |||||
| 日付タイプ | Issued | |||||
