{"created":"2023-05-15T14:49:30.540752+00:00","id":67792,"links":{},"metadata":{"_buckets":{"deposit":"8228b79e-3cf8-497e-92dd-05f498505a6a"},"_deposit":{"created_by":1,"id":"67792","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67792"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067792","sets":["10:28"]},"author_link":["666116","666117","666115","666113","666112","666114","666111"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-05-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effects of long-term administration of Zn-DTPA (diethyene-triamine-penta-actic acid) and CBMIDA [Catechol-3,6-bis(methyleiminodiaetic acid)] on plutonium-induced bone tumors and shortening of life span in rats were examined. One-hundred-twenty female rats were injected with doses of 18.5, 37, and 370 kBq/kg of plutonium-239. A daily intrperitoneally injected dose of 30 mmol/kg Ca-DTPA was administered to each of 40 rats of the 18.5, 37, and 370 kBq/kg of plutonium groups for first three days followed by the same dose of Zn-DTPA in orally administered in dinking water, while another 40 rats injected with 37 kBq/kg of plutonium were injected intraperitoneally with 30 mmol/kg CBMIDA for the first three days followed by oral administration. High urinary excretion of plutonium was observed for 14-21 days after plutonium injection in the chelating agent-treated groups. In the Zn-DTPA and CBMIDA treated groups, the mean life spans were significantly more prolonged compared with each corresponding (plutonium-injected) group. The incidences of bone tumors in the Zn-DTPA groups were reduced to zero from 10% in the 18.5 and 37 kBq/kg plutonium groups, while they increased to 10% from zero in the 370 kBq/kg plutonium group. The results indicated that human doses of Zn-DTPA and CBMIDA were effective in reducing plutonium-induced effects such as the shortening of life span and the induction of bone tumors in rats.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"11th International Congress of the International Radiation Protection Association","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukuda, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"666111","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iida, Haruzo"}],"nameIdentifiers":[{"nameIdentifier":"666112","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yan, Xueming"}],"nameIdentifiers":[{"nameIdentifier":"666113","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Yuyuan"}],"nameIdentifiers":[{"nameIdentifier":"666114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福田 俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"666115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"飯田 治三","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"666116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"厳 雪銘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"666117","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"A long-term treatment of chelating agents, Zn-DTPA and CBMIDA,reduces cancers and prevents shortening of life span in plutonium administered rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A long-term treatment of chelating agents, Zn-DTPA and CBMIDA,reduces cancers and prevents shortening of life span in plutonium administered rats"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-05-31"},"publish_date":"2004-05-31","publish_status":"0","recid":"67792","relation_version_is_last":true,"title":["A long-term treatment of chelating agents, Zn-DTPA and CBMIDA,reduces cancers and prevents shortening of life span in plutonium administered rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:33:39.967478+00:00"}