WEKO3
アイテム
Strain dependent differences in a quantitative histological study and expression analysis in irradiated murine lung
https://repo.qst.go.jp/records/67717
https://repo.qst.go.jp/records/677175f7a0b8e-5434-4b00-b3c5-f563cc18e292
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-02-24 | |||||
| タイトル | ||||||
| タイトル | Strain dependent differences in a quantitative histological study and expression analysis in irradiated murine lung | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Iwakawa, Mayumi
× Iwakawa, Mayumi× Noda, Syuuhei× Oota, Toshie× Tsuji, Atsushi× Imai, Takashi× 岩川 眞由美× 野田 秀平× 太田 敏江× 辻 厚至× 今井 高志 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although clinical observation can often reveal individual differences in the severity of lung fibrosis after radiation therapy, the actual influences of inherent individual factor is difficult to determine a clinical setting. In this paper, the usefulness of mouse model for research of heterogeneity in response of cancer treatment was investigated. C57BL/6J and C3H/HeMs mice were used for pathological and transcriotional experiments. The thorax of mice was locally irradiated at a dose of 10 or 20 Gy. Four-fold more CD44 positive cells had accumulated in the lungs of C3H/HeMs than of C57BL/6J mice. At sites of lung inflammation, HA accumulated at 12 hours after irradiation and the rapid resolution was achieved within 2 weeks in the lungs in both C57BL/6J mice and C3H/HheMs mice. An immunochemical investigation of C57BL/6J mice lungs revealed dense collagen accumulation at 8 weeks. The expression of Cap1, II18 and Rad51ap1 was constantly higher for 72 hours in C3H/HeMs mice than C57BL/6J mice. The expression of Mmp12 and Per3 was more induced in C3H/HeMs mice than C57BL/6J mice at 12 hours after irradiation. The expresion of Ltf was especially higher at 1 hour after iiradiation and that of Ifi202a was more induced at 72 hour in C57BL/6J mice than C3H/HeMs mice. Investigations into the mechanism of radiation-induced lung damage using animal models showed a powerful impact upon molecular studies of individual radiosensitivity. |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Mouse Models of Human Cancer (B7) | |||||
| 発表年月日 | ||||||
| 日付 | 2004-02-22 | |||||
| 日付タイプ | Issued | |||||
