{"created":"2023-05-15T14:49:27.183729+00:00","id":67717,"links":{},"metadata":{"_buckets":{"deposit":"4bfa240e-c407-47d7-aeaf-7e972ac52384"},"_deposit":{"created_by":1,"id":"67717","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67717"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067717","sets":["10:28"]},"author_link":["665486","665492","665488","665484","665483","665485","665489","665490","665487","665491"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-02-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although clinical observation can often reveal individual differences in the severity of lung fibrosis after radiation therapy, the actual influences of inherent individual factor is difficult to determine a clinical setting. In this paper, the usefulness of mouse model for research of heterogeneity in response of cancer treatment was investigated.\nC57BL/6J and C3H/HeMs mice were used for pathological and transcriotional experiments. The thorax of mice was locally irradiated at a dose of 10 or 20 Gy. Four-fold more CD44 positive cells had accumulated in the lungs of C3H/HeMs than of C57BL/6J mice. At sites of lung inflammation, HA accumulated at 12 hours after irradiation and the rapid resolution was achieved within 2 weeks in the lungs in both C57BL/6J mice and C3H/HheMs mice. An immunochemical investigation of C57BL/6J mice lungs revealed dense collagen accumulation at 8 weeks. The expression of Cap1, II18 and Rad51ap1 was constantly higher for 72 hours in C3H/HeMs mice than C57BL/6J mice. The expression of Mmp12 and Per3 was more induced in C3H/HeMs mice than C57BL/6J mice at 12 hours after irradiation. The expresion of Ltf was especially higher at 1 hour after iiradiation and that of Ifi202a was more induced at 72 hour in C57BL/6J mice than C3H/HeMs mice. Investigations into the mechanism of radiation-induced lung damage using animal models showed a powerful impact upon molecular studies of individual radiosensitivity.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Mouse Models of Human Cancer (B7)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"665483","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noda, Syuuhei"}],"nameIdentifiers":[{"nameIdentifier":"665484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oota, Toshie"}],"nameIdentifiers":[{"nameIdentifier":"665485","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"665486","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"665487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野田 秀平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665489","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"太田 敏江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665490","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"665492","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Strain dependent differences in a quantitative histological study and expression analysis in irradiated murine lung","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Strain dependent differences in a quantitative histological study and expression analysis in irradiated murine lung"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-02-24"},"publish_date":"2004-02-24","publish_status":"0","recid":"67717","relation_version_is_last":true,"title":["Strain dependent differences in a quantitative histological study and expression analysis in irradiated murine lung"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:34:31.227930+00:00"}