WEKO3
アイテム
Phase I/II trial of preoperative carbon ion therapy for patients with localized, resectable adenocarcinoma of the pancreas
https://repo.qst.go.jp/records/67501
https://repo.qst.go.jp/records/67501bac11d2d-7d09-4d58-a294-4de78c1f6910
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-10-09 | |||||
| タイトル | ||||||
| タイトル | Phase I/II trial of preoperative carbon ion therapy for patients with localized, resectable adenocarcinoma of the pancreas | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamada, Shigeru
× Yamada, Shigeru× Katou, Hirotoshi× Yamaguchi, Kazuya× Yasuda, Shigeo× Tsujii, Hirohiko× Saisho, Hiromitsu× 山田 滋× 加藤 博敏× 山口 和也× 安田 茂雄× 辻井 博彦× 税所 宏光 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We examined the effect of preoperative carbon ion therapy in terms of reducing the rate of local recurrence in patients undergoing resection for adenocarcinoma of the pancreas. Eighteen patients were enrolled into this trial. Median age was 62 years. Carbon ion therapy was given once daily, 4days a week, for a fixed 16 fractions in 4 weeks. The dose was set to 44.8GyE and escalated to 48.0GyE at 5% increments. All patients completed the scheduled treatment course. Three grade3 acute reactions occurred among 12 of the patients treated with a dose of 48.0GyE. Only one grade 3 portal vein reaction of them was estimated to be caused by carbon ion therapy. Of 18 patients, 12(67%) had resection. All tumor specimens pathologically revealed evidence of grade 2 treatment effects with significant fibrosis, hyalinization, and necrosis (Pathological grade2 is defined as a less than 33% active cancer cells.). Remarkable antitumor effects were observed. The overall actuarial local control rates were 100% and 100% at 1 year and at 2 years of follow-up respectively. No local failure was observed in any of the 18 enrolled patients. The above results suggest the superior usefulness of heavy ion radiotherapy in the treatment of pancreatic carcinoma to conventional photon radiotherapy. \n |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | HCPBM 2003(9th Workshop on Heavy Charged Particles in Biology and Medicine 2003) and ENLIGHT 2003(General Meeting of the European Network for Light Ion Hadrontherapy) | |||||
| 発表年月日 | ||||||
| 日付 | 2003-10-05 | |||||
| 日付タイプ | Issued | |||||
