@misc{oai:repo.qst.go.jp:00067501,
 author = {Yamada, Shigeru and Katou, Hirotoshi and Yamaguchi, Kazuya and Yasuda, Shigeo and Tsujii, Hirohiko and Saisho, Hiromitsu and 山田 滋 and 加藤 博敏 and 山口 和也 and 安田 茂雄 and 辻井 博彦 and 税所 宏光},
 month = {Oct},
 note = {We examined the effect of preoperative carbon ion therapy in terms of reducing the rate of local recurrence in patients undergoing resection for adenocarcinoma of the pancreas.
 Eighteen patients were enrolled into this trial. Median age was 62 years. Carbon ion therapy was given once daily, 4days a week, for a fixed 16 fractions in 4 weeks. The dose was set to 44.8GyE and escalated to 48.0GyE at 5% increments. All patients completed the scheduled treatment course. Three grade3 acute reactions occurred among 12 of the patients treated with a dose of 48.0GyE. Only one grade 3 portal vein reaction of them was estimated to be caused by carbon ion therapy. Of 18 patients, 12(67%) had resection. All tumor specimens pathologically revealed evidence of grade 2 treatment effects with significant fibrosis, hyalinization, and necrosis (Pathological grade2 is defined as a less than 33% active cancer cells.).  Remarkable antitumor effects were observed. The overall actuarial local control rates were 100% and 100% at 1 year and at 2 years of follow-up respectively. No local failure was observed in any of the 18 enrolled patients. The above results suggest the superior usefulness of heavy ion radiotherapy in the treatment of pancreatic carcinoma to conventional photon radiotherapy.
\n, HCPBM 2003(9th Workshop on Heavy Charged Particles in Biology and Medicine 2003) and ENLIGHT 2003(General Meeting of the European Network for Light Ion Hadrontherapy)},
 title = {Phase I/II trial of preoperative carbon ion therapy for patients with localized, resectable adenocarcinoma of the pancreas},
 year = {2003}
}