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Age dependency of the mechanism of radiogenic thymic lymphomas in B6C3F1 mice
https://repo.qst.go.jp/records/67461
https://repo.qst.go.jp/records/674615b951cd1-b60a-443c-b902-df516a423a00
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-09-08 | |||||
| タイトル | ||||||
| タイトル | Age dependency of the mechanism of radiogenic thymic lymphomas in B6C3F1 mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shimada, Yoshiya
× Shimada, Yoshiya× Nishimura, Mayumi× Kakinuma, Shizuko× Ogiu, Toshiaki× Kubo, Ayumi× Nagai, Junya× 島田 義也× 西村 まゆみ× 柿沼 志津子× 荻生 俊昭× 久保 歩× 永井 絢也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The relationship of leukemia incidence with age reflects the pathogenesis and may provide important evidence in any attempt to determine the mechanism of leukemogenesis. It has been assumed that form of leukemia of children differs from that of adults regarding, for instance, prognosis, that is possibly attributed to differences in disease biology. The aim of this study was to delineate the difference of molecular mechanism underlying lymphoma development, which distinguishes these two age groups. In the present study, we examined both K-ras mutation and Ikaros inactivation in thymic lymphomas (TLs) induced by exposure to X-rays of the B6C3F1 mice at the age of 4 week- or 25-week old. The results indicateed that K-ras mutation was more frequent in TLs from old mice than those from young ones (31% vs 17%), whereas Ikaros mutation appeared to be much more frequent in TLs from young mice. It suggests that age plays a role in the selection of molecular pathways for leukemogenesis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12th International congress of radiation research | |||||
| 発表年月日 | ||||||
| 日付 | 2003-08-22 | |||||
| 日付タイプ | Issued | |||||
