@misc{oai:repo.qst.go.jp:00067461,
 author = {Shimada, Yoshiya and Nishimura, Mayumi and Kakinuma, Shizuko and Ogiu, Toshiaki and Kubo, Ayumi and Nagai, Junya and 島田 義也 and 西村 まゆみ and 柿沼 志津子 and 荻生 俊昭 and 久保 歩 and 永井 絢也},
 month = {Aug},
 note = {The relationship of leukemia incidence with age reflects the pathogenesis and may provide important evidence in any attempt to determine the mechanism of leukemogenesis.  It has been assumed that form of leukemia of children differs from that of adults regarding, for instance, prognosis, that is possibly attributed to differences in disease biology.  The aim of this study was to delineate the difference of molecular mechanism underlying lymphoma development, which distinguishes these two age groups.  In the present study, we examined both K-ras mutation and Ikaros inactivation in thymic lymphomas (TLs) induced by exposure to X-rays of the B6C3F1 mice at the age of 4 week- or 25-week old.  The results indicateed that K-ras mutation was more frequent in TLs from old mice than those from young ones (31% vs 17%), whereas Ikaros mutation appeared to be much more frequent in TLs from young mice.  It suggests that age plays a role in the selection of molecular pathways for leukemogenesis., 12th International congress of radiation research},
 title = {Age dependency of the mechanism of radiogenic thymic lymphomas in B6C3F1 mice},
 year = {2003}
}