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Comparisons of pulmonary carcinogenesis in rats after inhalation exposures to 239Pu dioxide aerosols or X-ray irradiation
https://repo.qst.go.jp/records/67449
https://repo.qst.go.jp/records/67449c0b53758-9b6d-4c9d-8d77-62b5c77f8f0c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-08-29 | |||||
| タイトル | ||||||
| タイトル | Comparisons of pulmonary carcinogenesis in rats after inhalation exposures to 239Pu dioxide aerosols or X-ray irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Oghiso, Yoichi
× Oghiso, Yoichi× Yamada, Yutaka× Nakamura, Shingo× 小木曽 洋一× 山田 裕× 中村 慎吾 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Life time pulmonary carcinogenesis was compared in female Wistar rats following Internal exposures to alpha-particles or external X-ray irradiation to clarify dose responses and histogenesis of lung tumors. The dose response curve for lung tumor incidences was obtained with a peak incidence of about 97% at 5-6 Gy and a threshold-like dose range less than 0.2 Gy for malignant carcinomas after inhalation exposures of total 600 rats to submicron-sized and polydispersed Pu-239 dioxide aerosols. As compared to the dose response curves with the maximum incidence of approximately 40% at 10 Gy after either whole-body or thoracic X-ray irradiation in total 600 animals, relative biological effectiveness for Pu-induced lung tumors was estimated factor of about 11, while histological types and cellular origins of lung tumors were almost similarly identified to be type II cell- or Clara cell-derived adenomas and adenocarcinomas. For comparisons of mutations of the tumor suppressor gene, p53 related to pulmonary carcinogenesis, PCR-SSCP analysis in combination of direct sequence analysis was performed on DNA extracted from both histological sections of lung tumor specimens. The mutation frequency was about 13% with G to A or C to T transitional point mutations mostly in exons 5 and 6 in total 98 cases of Pu-induced lung tumors, while only 3% of mutation frequency with C to T transition in exon 6 was detected from total 33 cases of X-ray-induced lung tumors. These results indicate differences in radiation quality for pulmonary carcinogenesis in the rat between low LET X-ray and high LET alpha-particles, although the other types of genetic mutations could be associated with the developmental stages. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第１２回国際放射線研究会議（ＩＣＲＲ２００３） | |||||
| 発表年月日 | ||||||
| 日付 | 2003-08-22 | |||||
| 日付タイプ | Issued | |||||
