{"created":"2023-05-15T14:49:14.890848+00:00","id":67449,"links":{},"metadata":{"_buckets":{"deposit":"0fd31f4c-839e-41ec-a615-8dbf24447cdf"},"_deposit":{"created_by":1,"id":"67449","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67449"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067449","sets":["10:28"]},"author_link":["663016","663018","663019","663014","663015","663017"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2003-08-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Life time pulmonary carcinogenesis was compared in female Wistar rats following Internal exposures to alpha-particles or external X-ray irradiation to clarify dose responses and histogenesis of lung tumors. The dose response curve for lung tumor incidences was obtained with a peak incidence of about 97% at 5-6 Gy and a threshold-like dose range less than 0.2 Gy for malignant carcinomas after inhalation exposures of total 600 rats to submicron-sized and polydispersed Pu-239 dioxide aerosols. As compared to the dose response curves with the maximum incidence of approximately 40% at 10 Gy after either whole-body or thoracic X-ray irradiation in total 600 animals, relative biological effectiveness for Pu-induced lung tumors was estimated factor of about 11, while histological types and cellular origins of lung tumors were almost similarly identified to be type II cell- or Clara cell-derived adenomas and adenocarcinomas. For comparisons of mutations of the tumor suppressor gene, p53 related to pulmonary carcinogenesis, PCR-SSCP analysis in combination of direct sequence analysis was performed on DNA extracted from both histological sections of lung tumor specimens. The mutation frequency was about 13% with G to A or C to T transitional point mutations mostly in exons 5 and 6 in total 98 cases of Pu-induced lung tumors, while only 3% of mutation frequency with C to T transition in exon 6 was detected from total 33 cases of X-ray-induced lung tumors. These results indicate differences in radiation quality for pulmonary carcinogenesis in the rat between low LET X-ray and high LET alpha-particles, although the other types of genetic mutations could be associated with the developmental stages.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第１２回国際放射線研究会議（ＩＣＲＲ２００３）","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oghiso, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"663014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"663015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"663016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小木曽 洋一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 裕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 慎吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"663019","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Comparisons of pulmonary carcinogenesis in rats after inhalation exposures to 239Pu dioxide aerosols or X-ray irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparisons of pulmonary carcinogenesis in rats after inhalation exposures to 239Pu dioxide aerosols or X-ray irradiation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-08-29"},"publish_date":"2003-08-29","publish_status":"0","recid":"67449","relation_version_is_last":true,"title":["Comparisons of pulmonary carcinogenesis in rats after inhalation exposures to 239Pu dioxide aerosols or X-ray irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:37:36.806012+00:00"}