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Nitric oxide mediated bifunctional bystander effect induced by heavy-ion radiation in HSG cells
https://repo.qst.go.jp/records/67258
https://repo.qst.go.jp/records/672586555d58e-4974-4897-b8f4-51c8fa9e120e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-07-18 | |||||
| タイトル | ||||||
| タイトル | Nitric oxide mediated bifunctional bystander effect induced by heavy-ion radiation in HSG cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shao, Chunlin
× Shao, Chunlin× Furusawa, Yoshiya× Aoki, Mizuho× Matsumoto, Hideki× Ando, Koichi× Ｓｈａｏ Ｃｈｕｎｌｉｎ× 古澤 佳也× 青木 瑞穂× 松本 英樹× 安藤 興一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To investigate the medium-mediated bystander effect and its induction factor by co-cultivating unirradiated HSG neoplastic cells with HSG cells irradiated by a 290 MeV/u carbon beam. Results: An increase in cell proliferation relative to an unirradiated recipient HSG was found in the co-culture and its subculture, as well as micronucleus (MN) induction, which occurred in unirradiated recipient cells. 100 keV/mm carbon ion irradiation was found to be a much more efficient inducer of the medium-mediated bystander effect compared to 13 keV/mm carbon ion irradiation. The treatment of cells by PTIO, a specific scavenger to nitric oxide (NO), resulted in the elimination of such effects, which supports a role for NO in the medium-mediated bystander effect. As an oxidization product of NO, nitrite was indeed detected in the co-culture medium, and the dose response of its formation was also measured. Moreover, sper/NO, a NO generator, was used to directly examine the effect of NO on HSG cells. When the HSG cells were treated by sper/NO with a concentration of less than about 20 mM, cell proliferation was enhanced. However, MN was concurrently observed in the cells. Conclusions: This research first show that radiation-induced bystander effect was relative to LET; and NO, excreted from the heavy-ion irradiated HSG cells, as an important signal factor, played an dominate role in the medium-mediated bifunctional bystander effect. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 2nd International Workshop on Space Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2002-03-15 | |||||
| 日付タイプ | Issued | |||||
