{"created":"2023-05-15T14:49:06.175320+00:00","id":67258,"links":{},"metadata":{"_buckets":{"deposit":"88079ecf-04e6-4f02-9038-3a1a703efd2a"},"_deposit":{"created_by":1,"id":"67258","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"67258"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00067258","sets":["10:28"]},"author_link":["661190","661192","661196","661188","661189","661194","661195","661193","661191","661197"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2002-03-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To investigate the medium-mediated bystander effect and its induction factor by co-cultivating unirradiated HSG neoplastic cells with HSG cells irradiated by a 290 MeV/u carbon beam.   \nResults: An increase in cell proliferation relative to an unirradiated recipient HSG was found in the co-culture and its subculture, as well as micronucleus (MN) induction, which occurred in unirradiated recipient cells. 100 keV/mm carbon ion irradiation was found to be a much more efficient inducer of the medium-mediated bystander effect compared to 13 keV/mm carbon ion irradiation. The treatment of cells by PTIO, a specific scavenger to nitric oxide (NO), resulted in the elimination of such effects, which supports a role for NO in the medium-mediated bystander effect.  As an oxidization product of NO, nitrite was indeed detected in the co-culture medium, and the dose response of its formation was also measured. Moreover, sper/NO, a NO generator, was used to directly examine the effect of NO on HSG cells. When the HSG cells were treated by sper/NO with a concentration of less than about 20 mM, cell proliferation was enhanced. However, MN was concurrently observed in the cells.   \nConclusions: This research first show that radiation-induced bystander effect was relative to LET; and NO, excreted from the heavy-ion irradiated HSG cells, as an important signal factor, played an dominate role in the medium-mediated bifunctional bystander effect.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 2nd International Workshop on Space Radiation Research","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shao, Chunlin"}],"nameIdentifiers":[{"nameIdentifier":"661188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"661189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Mizuho"}],"nameIdentifiers":[{"nameIdentifier":"661190","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"661191","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"661192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｓｈａｏ Ｃｈｕｎｌｉｎ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"661193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"661194","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 瑞穂","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"661195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 英樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"661196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"661197","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Nitric oxide mediated bifunctional bystander effect induced by heavy-ion radiation in HSG cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nitric oxide mediated bifunctional bystander effect induced by heavy-ion radiation in HSG cells"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-07-18"},"publish_date":"2002-07-18","publish_status":"0","recid":"67258","relation_version_is_last":true,"title":["Nitric oxide mediated bifunctional bystander effect induced by heavy-ion radiation in HSG cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:39:50.678433+00:00"}