WEKO3
アイテム
Efficacy of combination use of intraperitoneal radioimmunotherapy and PET-guided surgery with 64Cu-labeled-cetuximab in a mice model of colon cancer peritoneal dissemination
https://repo.qst.go.jp/records/66847
https://repo.qst.go.jp/records/66847fb926fc5-281e-4658-b07b-9a271795b4c7
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-07-09 | |||||
| タイトル | ||||||
| タイトル | Efficacy of combination use of intraperitoneal radioimmunotherapy and PET-guided surgery with 64Cu-labeled-cetuximab in a mice model of colon cancer peritoneal dissemination | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshii, Yukie
× Yoshii, Yukie× Yoshimoto, Mitsuyoshi× Matsumoto, Hiroki× Tashima, Hideaki× Iwao, Yuma× Takuwa, Hiroyuki× Yoshida, Eiji× Wakizaka, Hidekatsu× Yamaya, Taiga× Zhang, Ming-Rong× Sugyo, Aya× Hanadate, Sayaka× Tsuji, Atsushi× Higashi, Tatsuya× 吉井 幸恵× 吉本 光喜× 松本 博樹× 田島 英朗× 岩男 悠真× 田桑 弘之× 吉田 英治× 脇坂 秀克× 山谷 泰賀× 張 明栄× 須尭 綾× 花舘 明香× 辻 厚至× 東 達也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Peritoneal dissemination is a frequent cause of death in colon cancer and it is particularly hard to improve the survival of patients with late-phase peritoneal dissemination. We have reported that intraperitoneal radioimmunotherapy (ipRIT) using a theranostic agent 64Cu-labeled anti-epidermal growth factor receptor antibody cetuximab was effective to treat peritoneal dissemination of small lesions. We have also reported that PET-guided surgery with this agent using OpenPET system, which has open space for conducting surgery while monitoring objects at high resolution in real-time PET, was useful to detect and resect intraperitoneal large tumor masses of unknown position. Based on these findings, we examined efficacy of combination use of ipRIT and PET-guided surgery with 64Cu-labeled cetuximab, to treat late-phase peritoneal dissemination of colon cancer, in a mouse model. Methods: Human colon cancer HCT116 cells stably expressing red fluorescent protein (HCT116-RFP) were intraperitoneally injected into a mouse. Four weeks later, mice with late-phase peritoneal dissemination were randomized into 4 groups (n = 8/group). For combination treatment with ipRIT and OpenPET-guided surgery, a therapeutic dose of 64Cu-labeled-cetuximab (22.2 MBq) was ip injected into mice for ipRIT, and OpenPET-guided surgery was performed at 48 h after administration. For comparison purposes, the ipRIT + sham operation, OpenPET-guided surgery-only, or sham operation-only (control) groups were also prepared. For the ipRIT + sham operation group, 64Cu-labeled-cetuximab (22.2 MBq) was injected in a similar manner and the sham operation consisting of resecting only the tumors observed with the naked eye was conducted without OpenPET observation. For the OpenPET-guided surgery-only group, mice were ip administered an imaging dose of 64Cu-labeled-cetuximab (7.4 MBq), and OpenPET-guided surgery was performed at 24 h after the administration. Results: Combination of ipRIT and OpenPET-guided surgery inhibited tumor growth and extended survival significantly compared to the sham operation-only control (P < 0.05). OpenPET-guided surgery alone and ipRIT with a sham operation slightly extended survival, but the differences were not significant compared to the sham operation-only control. Conclusions: We demonstrated the efficacy of a combination therapy of ipRIT and PET-guided surgery for late-phase peritoneal dissemination of colon cancer using a mouse model. Our data suggested that this method could provide a novel strategy to treat late-phase peritoneal dissemination from colon cancer. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | SNMMI 2018 Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2018-06-24 | |||||
| 日付タイプ | Issued | |||||
