{"created":"2023-05-15T14:48:48.015503+00:00","id":66847,"links":{},"metadata":{"_buckets":{"deposit":"00ac89c5-6d75-4ca6-bb6c-b1dc9b5cfbef"},"_deposit":{"created_by":1,"id":"66847","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66847"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066847","sets":["10:29"]},"author_link":["657236","657251","657239","657253","657233","657235","657238","657246","657243","657249","657247","657240","657245","657257","657234","657241","657248","657244","657255","657256","657254","657231","657237","657232","657252","657242","657250","657230"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-06-24","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Peritoneal dissemination is a frequent cause of death in colon cancer and it is particularly hard to improve the survival of patients with late-phase peritoneal dissemination. We have reported that intraperitoneal radioimmunotherapy (ipRIT) using a theranostic agent 64Cu-labeled anti-epidermal growth factor receptor antibody cetuximab was effective to treat peritoneal dissemination of small lesions. We have also reported that PET-guided surgery with this agent using OpenPET system, which has open space for conducting surgery while monitoring objects at high resolution in real-time PET, was useful to detect and resect intraperitoneal large tumor masses of unknown position. Based on these findings, we examined efficacy of combination use of ipRIT and PET-guided surgery with 64Cu-labeled cetuximab, to treat late-phase peritoneal dissemination of colon cancer, in a mouse model. Methods: Human colon cancer HCT116 cells stably expressing red fluorescent protein (HCT116-RFP) were intraperitoneally injected into a mouse. Four weeks later, mice with late-phase peritoneal dissemination were randomized into 4 groups (n = 8/group). For combination treatment with ipRIT and OpenPET-guided surgery, a therapeutic dose of 64Cu-labeled-cetuximab (22.2 MBq) was ip injected into mice for ipRIT, and OpenPET-guided surgery was performed at 48 h after administration. For comparison purposes, the ipRIT + sham operation, OpenPET-guided surgery-only, or sham operation-only (control) groups were also prepared. For the ipRIT + sham operation group, 64Cu-labeled-cetuximab (22.2 MBq) was injected in a similar manner and the sham operation consisting of resecting only the tumors observed with the naked eye was conducted without OpenPET observation. For the OpenPET-guided surgery-only group, mice were ip administered an imaging dose of 64Cu-labeled-cetuximab (7.4 MBq), and OpenPET-guided surgery was performed at 24 h after the administration. Results: Combination of ipRIT and OpenPET-guided surgery inhibited tumor growth and extended survival significantly compared to the sham operation-only control (P < 0.05). OpenPET-guided surgery alone and ipRIT with a sham operation slightly extended survival, but the differences were not significant compared to the sham operation-only control. Conclusions: We demonstrated the efficacy of a combination therapy of ipRIT and PET-guided surgery for late-phase peritoneal dissemination of colon cancer using a mouse model. Our data suggested that this method could provide a novel strategy to treat late-phase peritoneal dissemination from colon cancer.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"SNMMI 2018 Annual Meeting","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshii, Yukie"}],"nameIdentifiers":[{"nameIdentifier":"657230","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshimoto, Mitsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"657231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"657232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tashima, Hideaki"}],"nameIdentifiers":[{"nameIdentifier":"657233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwao, Yuma"}],"nameIdentifiers":[{"nameIdentifier":"657234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takuwa, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"657235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Eiji"}],"nameIdentifiers":[{"nameIdentifier":"657236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu"}],"nameIdentifiers":[{"nameIdentifier":"657237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaya, Taiga"}],"nameIdentifiers":[{"nameIdentifier":"657238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"657239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugyo, Aya"}],"nameIdentifiers":[{"nameIdentifier":"657240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanadate, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"657241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"657242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"657243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉井 幸恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉本 光喜","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657245","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 博樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657246","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田島 英朗","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657247","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩男 悠真","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657248","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田桑 弘之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657249","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 英治","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657250","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657251","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山谷 泰賀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657252","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657253","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"花舘 明香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657255","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"657257","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Efficacy of combination use of intraperitoneal radioimmunotherapy and PET-guided surgery with 64Cu-labeled-cetuximab in a mice model of colon cancer peritoneal dissemination","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Efficacy of combination use of intraperitoneal radioimmunotherapy and PET-guided surgery with 64Cu-labeled-cetuximab in a mice model of colon cancer peritoneal dissemination"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-09"},"publish_date":"2018-07-09","publish_status":"0","recid":"66847","relation_version_is_last":true,"title":["Efficacy of combination use of intraperitoneal radioimmunotherapy and PET-guided surgery with 64Cu-labeled-cetuximab in a mice model of colon cancer peritoneal dissemination"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:44:14.650090+00:00"}