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Our preclinical evidence suggested that [18F]PM-PBB3 could capture tau deposits in living brains with high contrast and favorable kinetics. Here, we conducted a head-to-head comparison between PET data obtained using [11C]PBB3 and [18F]PM-PBB3 in patients with Alzheimer’s disease (AD) and non-AD tauopathy.\nMethods:\nPatients with AD and progressive supranuclear palsy (PSP), and healthy controls (HCs) underwent three PET scans with [11C]PiB, [11C]PBB3, and [18F]PM-PBB3. In the scan with [18F]PM-PBB3, arterial blood sampling was performed to determine binding potential (BPND) of the radioligand based on a compartment model. We also calculated BPND by a reference tissue model and standardized uptake value ratio (SUVR) using the cerebellum gray matter as reference. These estimates were compared to SUVR values of [11C]PBB3 in each subject.\nResults:\nThe BPND values of [18F]PM-PBB3 by a reference tissue model and SUVR were in good agreement with those by a compartment model. 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  1. 学会発表・講演等
  2. 口頭発表

A head-to-head comparison between [11C]PBB3 and [18F]PM-PBB3 in patients with AD and non-AD tauopathy

https://repo.qst.go.jp/records/66599
https://repo.qst.go.jp/records/66599
34e5f115-6f4c-4cc4-933d-c6350ff0a436
Item type 会議発表用資料 / Presentation(1)
公開日 2018-01-22
タイトル
タイトル A head-to-head comparison between [11C]PBB3 and [18F]PM-PBB3 in patients with AD and non-AD tauopathy
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 久保田, 学

× 久保田, 学

WEKO 654982

久保田, 学

Search repository
島田, 斉

× 島田, 斉

WEKO 654983

島田, 斉

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互, 健二

× 互, 健二

WEKO 654984

互, 健二

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北村, 聡一郎

× 北村, 聡一郎

WEKO 654985

北村, 聡一郎

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小野, 麻衣子

× 小野, 麻衣子

WEKO 654986

小野, 麻衣子

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木村, 泰之

× 木村, 泰之

WEKO 654987

木村, 泰之

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市瀬, 正則

× 市瀬, 正則

WEKO 654988

市瀬, 正則

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篠遠, 仁

× 篠遠, 仁

WEKO 654989

篠遠, 仁

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高畑, 圭輔

× 高畑, 圭輔

WEKO 654990

高畑, 圭輔

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山本, 保天

× 山本, 保天

WEKO 654991

山本, 保天

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佐野, 康徳

× 佐野, 康徳

WEKO 654992

佐野, 康徳

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関, 千江

× 関, 千江

WEKO 654993

関, 千江

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Tempest, Paul

× Tempest, Paul

WEKO 654994

Tempest, Paul

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Jang, Ming-Kuei

× Jang, Ming-Kuei

WEKO 654995

Jang, Ming-Kuei

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Seibyl, John

× Seibyl, John

WEKO 654996

Seibyl, John

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Barret, Olivier

× Barret, Olivier

WEKO 654997

Barret, Olivier

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Alagille, David

× Alagille, David

WEKO 654998

Alagille, David

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Marek, Kenneth

× Marek, Kenneth

WEKO 654999

Marek, Kenneth

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張, 明栄

× 張, 明栄

WEKO 655000

張, 明栄

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須原, 哲也

× 須原, 哲也

WEKO 655001

須原, 哲也

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樋口, 真人

× 樋口, 真人

WEKO 655002

樋口, 真人

Search repository
久保田 学

× 久保田 学

WEKO 655003

en 久保田 学

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島田 斉

× 島田 斉

WEKO 655004

en 島田 斉

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互 健二

× 互 健二

WEKO 655005

en 互 健二

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北村 聡一郎

× 北村 聡一郎

WEKO 655006

en 北村 聡一郎

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小野 麻衣子

× 小野 麻衣子

WEKO 655007

en 小野 麻衣子

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木村 泰之

× 木村 泰之

WEKO 655008

en 木村 泰之

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市瀬 正則

× 市瀬 正則

WEKO 655009

en 市瀬 正則

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篠遠 仁

× 篠遠 仁

WEKO 655010

en 篠遠 仁

Search repository
高畑 圭輔

× 高畑 圭輔

WEKO 655011

en 高畑 圭輔

Search repository
山本 保天

× 山本 保天

WEKO 655012

en 山本 保天

Search repository
佐野 康徳

× 佐野 康徳

WEKO 655013

en 佐野 康徳

Search repository
関 千江

× 関 千江

WEKO 655014

en 関 千江

Search repository
張 明栄

× 張 明栄

WEKO 655015

en 張 明栄

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須原 哲也

× 須原 哲也

WEKO 655016

en 須原 哲也

Search repository
樋口 真人

× 樋口 真人

WEKO 655017

en 樋口 真人

Search repository
抄録
内容記述タイプ Abstract
内容記述 Background:
We recently developed a novel fluorinated tau PET ligand, [18F]PM-PBB3, to improve characteristics of [11C]PBB3. Our preclinical evidence suggested that [18F]PM-PBB3 could capture tau deposits in living brains with high contrast and favorable kinetics. Here, we conducted a head-to-head comparison between PET data obtained using [11C]PBB3 and [18F]PM-PBB3 in patients with Alzheimer’s disease (AD) and non-AD tauopathy.
Methods:
Patients with AD and progressive supranuclear palsy (PSP), and healthy controls (HCs) underwent three PET scans with [11C]PiB, [11C]PBB3, and [18F]PM-PBB3. In the scan with [18F]PM-PBB3, arterial blood sampling was performed to determine binding potential (BPND) of the radioligand based on a compartment model. We also calculated BPND by a reference tissue model and standardized uptake value ratio (SUVR) using the cerebellum gray matter as reference. These estimates were compared to SUVR values of [11C]PBB3 in each subject.
Results:
The BPND values of [18F]PM-PBB3 by a reference tissue model and SUVR were in good agreement with those by a compartment model. Compared to [11C]PBB3, the peak brain radioactivity and contrast for tau lesions yielded by [18F]PM-PBB3 were almost double of those produced by [11C]PBB3. Unlike [11C]PBB3, [18F]PM-PBB3 showed minimal off-site binding in the brain parenchyma including the striatum. Binding of [18F]PM-PBB3 in the brainstem was not evident in AD patients and HCs, but was prominent in PSP patients, resulting in a vivid contrast between PSP patients and the other subjects.
Conclusion:
The current results indicate that [18F]PM-PBB3 would be a promising PET ligand to quantify tau accumulation in AD and PSP patients with suitable kinetics and high contrast. The wide dynamic range and minimal parenchymal off-site binding of [18F]PM-PBB3 would allow its application to differentiations among AD, non-AD tauopathies and HC by both visual inspection and quantitative assessments on an individual basis in a clinical workup.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 12th Human Amyloid Imaging
発表年月日
日付 2018-01-17
日付タイプ Issued
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