{"_buckets": {"deposit": "b41b9a8d-7321-49ab-ae46-6eb1014c90f0"}, "_deposit": {"created_by": 1, "id": "66599", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "66599"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00066599", "sets": ["29"]}, "author_link": ["655003", "654991", "654995", "655013", "655017", "655000", "655015", "654994", "654992", "654998", "654983", "654997", "655001", "654990", "654987", "654985", "655005", "655006", "654988", "655014", "654984", "654999", "654996", "655016", "654989", "655004", "654986", "654982", "655012", "655009", "655002", "655007", "655010", "655008", "654993", "655011"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2018-01-17", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background:\nWe recently developed a novel fluorinated tau PET ligand, [18F]PM-PBB3, to improve characteristics of [11C]PBB3. Our preclinical evidence suggested that [18F]PM-PBB3 could capture tau deposits in living brains with high contrast and favorable kinetics. Here, we conducted a head-to-head comparison between PET data obtained using [11C]PBB3 and [18F]PM-PBB3 in patients with Alzheimer’s disease (AD) and non-AD tauopathy.\nMethods:\nPatients with AD and progressive supranuclear palsy (PSP), and healthy controls (HCs) underwent three PET scans with [11C]PiB, [11C]PBB3, and [18F]PM-PBB3. In the scan with [18F]PM-PBB3, arterial blood sampling was performed to determine binding potential (BPND) of the radioligand based on a compartment model. We also calculated BPND by a reference tissue model and standardized uptake value ratio (SUVR) using the cerebellum gray matter as reference. These estimates were compared to SUVR values of [11C]PBB3 in each subject.\nResults:\nThe BPND values of [18F]PM-PBB3 by a reference tissue model and SUVR were in good agreement with those by a compartment model. Compared to [11C]PBB3, the peak brain radioactivity and contrast for tau lesions yielded by [18F]PM-PBB3 were almost double of those produced by [11C]PBB3. Unlike [11C]PBB3, [18F]PM-PBB3 showed minimal off-site binding in the brain parenchyma including the striatum. Binding of [18F]PM-PBB3 in the brainstem was not evident in AD patients and HCs, but was prominent in PSP patients, resulting in a vivid contrast between PSP patients and the other subjects.\nConclusion:\nThe current results indicate that [18F]PM-PBB3 would be a promising PET ligand to quantify tau accumulation in AD and PSP patients with suitable kinetics and high contrast. The wide dynamic range and minimal parenchymal off-site binding of [18F]PM-PBB3 would allow its application to differentiations among AD, non-AD tauopathies and HC by both visual inspection and quantitative assessments on an individual basis in a clinical workup.", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要（会議名, 開催地, 会期, 主催者等）", "attribute_value_mlt": [{"subitem_description": "12th Human Amyloid Imaging", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "久保田, 学"}], "nameIdentifiers": [{"nameIdentifier": "654982", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "島田, 斉"}], "nameIdentifiers": [{"nameIdentifier": "654983", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "互, 健二"}], "nameIdentifiers": [{"nameIdentifier": "654984", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "北村, 聡一郎"}], "nameIdentifiers": [{"nameIdentifier": "654985", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小野, 麻衣子"}], "nameIdentifiers": [{"nameIdentifier": "654986", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "木村, 泰之"}], "nameIdentifiers": [{"nameIdentifier": "654987", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "市瀬, 正則"}], "nameIdentifiers": [{"nameIdentifier": "654988", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "篠遠, 仁"}], "nameIdentifiers": [{"nameIdentifier": "654989", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高畑, 圭輔"}], "nameIdentifiers": [{"nameIdentifier": "654990", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山本, 保天"}], "nameIdentifiers": [{"nameIdentifier": "654991", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐野, 康徳"}], "nameIdentifiers": [{"nameIdentifier": "654992", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "関, 千江"}], "nameIdentifiers": [{"nameIdentifier": "654993", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tempest, Paul"}], "nameIdentifiers": [{"nameIdentifier": "654994", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jang, Ming-Kuei"}], "nameIdentifiers": [{"nameIdentifier": "654995", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Seibyl, John"}], "nameIdentifiers": [{"nameIdentifier": "654996", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Barret, Olivier"}], "nameIdentifiers": [{"nameIdentifier": "654997", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Alagille, David"}], "nameIdentifiers": [{"nameIdentifier": "654998", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Marek, Kenneth"}], "nameIdentifiers": [{"nameIdentifier": "654999", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張, 明栄"}], "nameIdentifiers": [{"nameIdentifier": "655000", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須原, 哲也"}], "nameIdentifiers": [{"nameIdentifier": "655001", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口, 真人"}], "nameIdentifiers": [{"nameIdentifier": "655002", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "久保田 学", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655003", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "島田 斉", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655004", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "互 健二", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655005", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "北村 聡一郎", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655006", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小野 麻衣子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655007", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "木村 泰之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655008", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "市瀬 正則", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655009", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "篠遠 仁", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655010", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高畑 圭輔", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655011", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山本 保天", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655012", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐野 康徳", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655013", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "関 千江", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655014", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張 明栄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655015", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須原 哲也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655016", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口 真人", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "655017", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "A head-to-head comparison between [11C]PBB3 and [18F]PM-PBB3 in patients with AD and non-AD tauopathy", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A head-to-head comparison between [11C]PBB3 and [18F]PM-PBB3 in patients with AD and non-AD tauopathy"}]}, "item_type_id": "10005", "owner": "1", "path": ["29"], "permalink_uri": "https://repo.qst.go.jp/records/66599", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-01-22"}, "publish_date": "2018-01-22", "publish_status": "0", "recid": "66599", "relation": {}, "relation_version_is_last": true, "title": ["A head-to-head comparison between [11C]PBB3 and [18F]PM-PBB3 in patients with AD and non-AD tauopathy"], "weko_shared_id": -1}