{"created":"2023-05-15T14:48:36.795057+00:00","id":66599,"links":{},"metadata":{"_buckets":{"deposit":"b41b9a8d-7321-49ab-ae46-6eb1014c90f0"},"_deposit":{"created_by":1,"id":"66599","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66599"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066599","sets":["10:29"]},"author_link":["655003","654991","654995","655013","655017","655000","655015","654994","654992","654998","654983","654997","655001","654990","654987","654985","655005","655006","654988","655014","654984","654999","654996","655016","654989","655004","654986","654982","655012","655009","655002","655007","655010","655008","654993","655011"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-01-17","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:\nWe recently developed a novel fluorinated tau PET ligand, [18F]PM-PBB3, to improve characteristics of [11C]PBB3. Our preclinical evidence suggested that [18F]PM-PBB3 could capture tau deposits in living brains with high contrast and favorable kinetics. Here, we conducted a head-to-head comparison between PET data obtained using [11C]PBB3 and [18F]PM-PBB3 in patients with Alzheimer’s disease (AD) and non-AD tauopathy.\nMethods:\nPatients with AD and progressive supranuclear palsy (PSP), and healthy controls (HCs) underwent three PET scans with [11C]PiB, [11C]PBB3, and [18F]PM-PBB3. In the scan with [18F]PM-PBB3, arterial blood sampling was performed to determine binding potential (BPND) of the radioligand based on a compartment model. We also calculated BPND by a reference tissue model and standardized uptake value ratio (SUVR) using the cerebellum gray matter as reference. These estimates were compared to SUVR values of [11C]PBB3 in each subject.\nResults:\nThe BPND values of [18F]PM-PBB3 by a reference tissue model and SUVR were in good agreement with those by a compartment model. Compared to [11C]PBB3, the peak brain radioactivity and contrast for tau lesions yielded by [18F]PM-PBB3 were almost double of those produced by [11C]PBB3. Unlike [11C]PBB3, [18F]PM-PBB3 showed minimal off-site binding in the brain parenchyma including the striatum. Binding of [18F]PM-PBB3 in the brainstem was not evident in AD patients and HCs, but was prominent in PSP patients, resulting in a vivid contrast between PSP patients and the other subjects.\nConclusion:\nThe current results indicate that [18F]PM-PBB3 would be a promising PET ligand to quantify tau accumulation in AD and PSP patients with suitable kinetics and high contrast. The wide dynamic range and minimal parenchymal off-site binding of [18F]PM-PBB3 would allow its application to differentiations among AD, non-AD tauopathies and HC by both visual inspection and quantitative assessments on an individual basis in a clinical workup.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"12th Human Amyloid Imaging","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"久保田, 学"}],"nameIdentifiers":[{"nameIdentifier":"654982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"654983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"互, 健二"}],"nameIdentifiers":[{"nameIdentifier":"654984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北村, 聡一郎"}],"nameIdentifiers":[{"nameIdentifier":"654985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野, 麻衣子"}],"nameIdentifiers":[{"nameIdentifier":"654986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 泰之"}],"nameIdentifiers":[{"nameIdentifier":"654987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"市瀬, 正則"}],"nameIdentifiers":[{"nameIdentifier":"654988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"654989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑, 圭輔"}],"nameIdentifiers":[{"nameIdentifier":"654990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 保天"}],"nameIdentifiers":[{"nameIdentifier":"654991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐野, 康徳"}],"nameIdentifiers":[{"nameIdentifier":"654992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"654993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tempest, Paul"}],"nameIdentifiers":[{"nameIdentifier":"654994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jang, Ming-Kuei"}],"nameIdentifiers":[{"nameIdentifier":"654995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seibyl, John"}],"nameIdentifiers":[{"nameIdentifier":"654996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Barret, Olivier"}],"nameIdentifiers":[{"nameIdentifier":"654997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Alagille, David"}],"nameIdentifiers":[{"nameIdentifier":"654998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Marek, Kenneth"}],"nameIdentifiers":[{"nameIdentifier":"654999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"655000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"655001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"655002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保田 学","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"互 健二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北村 聡一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野 麻衣子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"市瀬 正則","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畑 圭輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本 保天","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐野 康徳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"655017","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"A head-to-head comparison between [11C]PBB3 and [18F]PM-PBB3 in patients with AD and non-AD tauopathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A head-to-head comparison between [11C]PBB3 and [18F]PM-PBB3 in patients with AD and non-AD tauopathy"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-01-22"},"publish_date":"2018-01-22","publish_status":"0","recid":"66599","relation_version_is_last":true,"title":["A head-to-head comparison between [11C]PBB3 and [18F]PM-PBB3 in patients with AD and non-AD tauopathy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:47:10.065748+00:00"}