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重粒子線照射の線エネルギー付与(LET)の違いにおける腫瘍免疫応答に関する研究
https://repo.qst.go.jp/records/66313
https://repo.qst.go.jp/records/663130194b328-9ff1-4294-9539-cc44d5aab677
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-05-08 | |||||
| タイトル | ||||||
| タイトル | 重粒子線照射の線エネルギー付与(LET)の違いにおける腫瘍免疫応答に関する研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
小此木, 範之
× 小此木, 範之× 小此木 範之 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We previously reported that comparable levels of high mobility group box 1(HMGB1), which play a pivotal role in activating antigen-specific T-cell responses, were detected after irradiation with iso-survival doses of X-rays and carbon-ion beams (CIB). Here, we examined whether there is a difference in release amount of HMGB1 in different linear energy transfer (LET) in iso-survival doses of CIB from human cancer cell lines. The study examined four cell lines: TE2, KYSE70, Hela, and Siha. The proportion of cells surviving after CIB irradiation in different LET was assessed in a clonogenic assay. The D10 was calculated using a linear-quadratic model. HMGB1 levels in the culture supematants were assessed by an ELISA. The D10 dose for 13 kev /µm of CIB in TE2, KYSE70, Hela, and Siha cells was 1.0, 2.8, 3.9, and 4.1 Gy respectively, whereas that for 70 kev /µm CIB was 0.5, 1.4, 1.9 and 2.2 Gy, respectively. CIB significantly increased HMGB1 levels in the culture supematants of all cell lines at 72 h post-irradiation with a D10 dose. Furthermore, 70 kev /µm of CIB significantly increased HMGBl levels in the culture supematants of KYSE70 and Siha at 72 h post-irradiation, comparing to 13 kev /µm of CIB. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成28年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2017-04-17 | |||||
| 日付タイプ | Issued | |||||
