{"created":"2023-05-15T14:48:23.695107+00:00","id":66313,"links":{},"metadata":{"_buckets":{"deposit":"a70936f4-ae84-44f8-b91d-bdac3cef8482"},"_deposit":{"created_by":1,"id":"66313","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"66313"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00066313","sets":["10:29"]},"author_link":["652500","652499"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-04-17","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We previously reported that comparable levels of high mobility group box 1(HMGB1), which play a pivotal role in activating antigen-specific T-cell responses, were detected after irradiation with iso-survival doses of X-rays and carbon-ion beams (CIB). Here, we examined whether there is a difference in release amount of HMGB1 in different linear energy transfer (LET) in iso-survival doses of CIB from human cancer cell lines. The study examined four cell lines: TE2, KYSE70, Hela, and Siha. The proportion of cells surviving after CIB irradiation in different LET was assessed in a clonogenic assay. The D10 was calculated using a linear-quadratic model.\nHMGB1 levels in the culture supematants were  assessed by an ELISA. The D10 dose for 13 kev /µm of CIB in TE2, KYSE70, Hela, and Siha cells was 1.0, 2.8, 3.9, and 4.1 Gy respectively, whereas that for 70 kev /µm CIB was 0.5, 1.4, 1.9 and 2.2 Gy, respectively. CIB significantly increased HMGB1 levels in the culture supematants of all cell lines at 72 h post-irradiation with a D10 dose. Furthermore, 70 kev /µm of CIB significantly increased HMGBl levels in the culture supematants of KYSE70 and Siha at 72 h post-irradiation, comparing to 13 kev /µm of CIB.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"平成28年度HIMAC共同利用研究成果発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小此木, 範之"}],"nameIdentifiers":[{"nameIdentifier":"652499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小此木 範之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"652500","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"重粒子線照射の線エネルギー付与(LET)の違いにおける腫瘍免疫応答に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"重粒子線照射の線エネルギー付与(LET)の違いにおける腫瘍免疫応答に関する研究"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-08"},"publish_date":"2017-05-08","publish_status":"0","recid":"66313","relation_version_is_last":true,"title":["重粒子線照射の線エネルギー付与(LET)の違いにおける腫瘍免疫応答に関する研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:50:21.024089+00:00"}