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First Clinical Test of the Helmet-Chin PET Prototype
https://repo.qst.go.jp/records/66028
https://repo.qst.go.jp/records/66028ee3d2b94-f479-4b78-a0c4-84efd669d7b9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-11-22 | |||||
| タイトル | ||||||
| タイトル | First Clinical Test of the Helmet-Chin PET Prototype | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tashima, Hideaki
× Tashima, Hideaki× Yoshida, Eiji× Iwao, Yuma× Wakizaka, Hidekatsu× Tazawa, Shusaku× Seki, Chie× Kimura, Yasuyuki× Suhara, Tetsuya× Yamaya, Taiga× Tashima, Hideaki× Yoshida, Eiji× Iwao, Yuma× Wakizaka, Hidekatsu× Tazawa, Shusaku× Seki, Chie× Kimura, Yasuyuki× Suhara, Tetsuya× Yamaya, Taiga |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Dementia is a severe problem in aging societies. There is a strong potential demand for high-sensitivity, high-resolution, and low-cost brain positron emission tomography (PET) imaging for its early diagnosis. Therefore, we have proposed the helmet-chin PET, a novel geometry for high-sensitivity brain imaging based on a hemispheric arrangement of detectors. For a proof-of-concept, we developed the first prototype using 4-layered depth-of-interaction (DOI) detectors. The helmet-chin PET prototype used 54 DOI detectors, each of which consisted of 16×16×4 Zr-doped GSO crystals (2.8×2.8×7.5 mm3) and a high sensitivity 64-channel flat-panel photomultiplier tube. In the prototype, 47 detectors were used to form a hemisphere of 25 cm inner diameter and 50 cm outer diameter, and 7 detectors were used for the chin detector. In this study, we conducted the first clinical test with a healthy volunteer. First, we compared sensitivity with a whole-body time-of-flight-PET (Biograph mCT Flow 64-4R PET/CT system, Siemens Medical Solutions USA, Inc.) to determine injection activity. As a result, the sensitivity of the helmet-chin PET prototype for the brain region was almost twice as high as that of the mCT, even though the number of detectors was less than 30% that of the mCT. Then a healthy volunteer was measured by the mCT for 15 min beginning 60 min after 18F-FDG injection of 70 MBq and by the helmet-chin PET for 18 min beginning 85 min after the injection. For the first clinical test, we could obtain a clear image of the brain with low radioactivity injection. We analyzed region of interest (ROI) values based on the anatomical structure. As a result, ROI values measured by the helmet-chin PET prototype and the mCT were in good agreement. The first clinical test showed promising performance of the helmet-chin PET for highly sensitive brain imaging. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2016 IEEE NSS/MIC | |||||
| 発表年月日 | ||||||
| 日付 | 2016-11-05 | |||||
| 日付タイプ | Issued | |||||
