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Theranostic application of cancer targeting probes labeled with various copper radioisotopes
https://repo.qst.go.jp/records/65842
https://repo.qst.go.jp/records/658424e298e1f-6695-4b1d-a93c-21a52d3c345f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-12-28 | |||||
| タイトル | ||||||
| タイトル | Theranostic application of cancer targeting probes labeled with various copper radioisotopes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Saga, Tsuneo
× Saga, Tsuneo× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | At present, various copper radioisotopes can be produced by cyclotrons and many molecular imaging probes labeled with positron-emitting copper radioisotopes are utilized for PET imaging of cancer. Our institution has produced 62Zn/62Cu generators and delivered them to several institutions in Japan. In each institution, they eluted 62 Cu from the generator and label 62Cu-ATSM, a PET probe for hypoxia, and performed clinical studies of hypoxia imaging for patients with brain tumor, head and neck cancer and lung cancer patients. We have also developed 64Culabeled tetramer of cyclic RGD peptide, targeting αvβ3 integrins expressed on various cancer cells and activated endothelial cells during angiogenesis, for the PET imaging of cancer and monitoring of anti-angiogenesis therapy. In addition to PET imaging, copper radioisotopes that emit β-rays and Auger electrons can be applied for treatment, socalled internal radiotherapy. For example, 64Cu emits not only positrons but also β-rays and Auger electrons, and can be regarded as a “theranostic” radioisotope. We have proved the potential of 64Cu-ATSM as an internal radiotherapy agent targeting hypoxic microenvironment, which is rich in cancer stem cells. We have also applied the tetramer of cyclic RGD peptide labeled with 64Cu for experimental internal radiotherapy and obtained promising results. Recently, we are trying to optimize the cyclotron production of 67Cu that emits β-rays for possible application for internal radiotherapy. In this symposium, I would like to introduce our research results aiming for the theranostic application of cancer targeting probes labeled with various copper radioisotopes. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The International Chemical Congress of Pacific Basin Societies 2015 | |||||
| 発表年月日 | ||||||
| 日付 | 2015-12-16 | |||||
| 日付タイプ | Issued | |||||
