{"created":"2023-05-15T14:48:02.488551+00:00","id":65842,"links":{},"metadata":{"_buckets":{"deposit":"0ea5227e-38b9-4914-a555-f94e8e395ea6"},"_deposit":{"created_by":1,"id":"65842","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65842"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065842","sets":["10:29"]},"author_link":["648628","648627"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-12-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"At present, various copper radioisotopes can be produced by cyclotrons and many molecular imaging\nprobes labeled with positron-emitting copper radioisotopes are utilized for PET imaging of cancer. Our institution has\nproduced 62Zn/62Cu generators and delivered them to several institutions in Japan. In each institution, they eluted 62\nCu from the generator and label 62Cu-ATSM, a PET probe for hypoxia, and performed clinical studies of hypoxia\nimaging for patients with brain tumor, head and neck cancer and lung cancer patients. We have also developed 64Culabeled\ntetramer of cyclic RGD peptide, targeting αvβ3 integrins expressed on various cancer cells and activated\nendothelial cells during angiogenesis, for the PET imaging of cancer and monitoring of anti-angiogenesis therapy. In\naddition to PET imaging, copper radioisotopes that emit β-rays and Auger electrons can be applied for treatment, socalled\ninternal radiotherapy. For example, 64Cu emits not only positrons but also β-rays and Auger electrons, and can\nbe regarded as a “theranostic” radioisotope. We have proved the potential of 64Cu-ATSM as an internal radiotherapy\nagent targeting hypoxic microenvironment, which is rich in cancer stem cells. We have also applied the tetramer of\ncyclic RGD peptide labeled with 64Cu for experimental internal radiotherapy and obtained promising results. Recently,\nwe are trying to optimize the cyclotron production of 67Cu that emits β-rays for possible application for internal\nradiotherapy. In this symposium, I would like to introduce our research results aiming for the theranostic application of\ncancer targeting probes labeled with various copper radioisotopes.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The  International Chemical Congress of Pacific Basin Societies 2015","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"648627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"648628","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Theranostic application of cancer targeting probes labeled with various copper radioisotopes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Theranostic application of cancer targeting probes labeled with various copper radioisotopes"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-28"},"publish_date":"2015-12-28","publish_status":"0","recid":"65842","relation_version_is_last":true,"title":["Theranostic application of cancer targeting probes labeled with various copper radioisotopes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:55:39.227162+00:00"}