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Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB

https://repo.qst.go.jp/records/65826
https://repo.qst.go.jp/records/65826
fd3202ab-f2b5-44a2-9f84-432b62f6fa28
Item type 会議発表用資料 / Presentation(1)
公開日 2015-08-05
タイトル
タイトル Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Takahata, Keisuke

× Takahata, Keisuke

WEKO 836606

Takahata, Keisuke

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Shimada, Hitoshi

× Shimada, Hitoshi

WEKO 836607

Shimada, Hitoshi

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Higuchi, Makoto

× Higuchi, Makoto

WEKO 836608

Higuchi, Makoto

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Shinotoh, Hitoshi

× Shinotoh, Hitoshi

WEKO 836609

Shinotoh, Hitoshi

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Kimura, Yasuyuki

× Kimura, Yasuyuki

WEKO 836610

Kimura, Yasuyuki

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Kitamura, Soichiro

× Kitamura, Soichiro

WEKO 836611

Kitamura, Soichiro

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Endo, Hironobu

× Endo, Hironobu

WEKO 836612

Endo, Hironobu

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Niwa, Fumitoshi

× Niwa, Fumitoshi

WEKO 836613

Niwa, Fumitoshi

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Moriguchi, Sho

× Moriguchi, Sho

WEKO 836614

Moriguchi, Sho

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Ichise, Masanori

× Ichise, Masanori

WEKO 836615

Ichise, Masanori

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Sahara, Naruhiko

× Sahara, Naruhiko

WEKO 836616

Sahara, Naruhiko

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Mimura, Masaru

× Mimura, Masaru

WEKO 836617

Mimura, Masaru

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Kato, Motoichiro

× Kato, Motoichiro

WEKO 836618

Kato, Motoichiro

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Yamada, Makiko

× Yamada, Makiko

WEKO 836619

Yamada, Makiko

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Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 836620

Suhara, Tetsuya

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Takahata, Keisuke

× Takahata, Keisuke

WEKO 836621

en Takahata, Keisuke

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Shimada, Hitoshi

× Shimada, Hitoshi

WEKO 836622

en Shimada, Hitoshi

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Higuchi, Makoto

× Higuchi, Makoto

WEKO 836623

en Higuchi, Makoto

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Shinoto, Hitoshi

× Shinoto, Hitoshi

WEKO 836624

en Shinoto, Hitoshi

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Kimura, Yasuyuki

× Kimura, Yasuyuki

WEKO 836625

en Kimura, Yasuyuki

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Kitamura, Soichiro

× Kitamura, Soichiro

WEKO 836626

en Kitamura, Soichiro

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Endo, Hironobu

× Endo, Hironobu

WEKO 836627

en Endo, Hironobu

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Niwa, Fumitoshi

× Niwa, Fumitoshi

WEKO 836628

en Niwa, Fumitoshi

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Moriguchi, Sho

× Moriguchi, Sho

WEKO 836629

en Moriguchi, Sho

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Ichise, Masanori

× Ichise, Masanori

WEKO 836630

en Ichise, Masanori

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Sahara, Naruhiko

× Sahara, Naruhiko

WEKO 836631

en Sahara, Naruhiko

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Mimura, Masaru

× Mimura, Masaru

WEKO 836632

en Mimura, Masaru

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Kato, Motoichiro

× Kato, Motoichiro

WEKO 836633

en Kato, Motoichiro

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Yamada, Makiko

× Yamada, Makiko

WEKO 836634

en Yamada, Makiko

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Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 836635

en Suhara, Tetsuya

Search repository
抄録
内容記述タイプ Abstract
内容記述 Backgrounds: Chronic traumatic encephalopathy (CTE) is a delayed-onset neurodegenerative disease, which occurs several years after traumatic brain injury (TBI). Pathologically, CTE is characterized by abnormal accumulations including tau changes, amyloid-beta proteins. Using a novel tau ligand [11C]PBB3 and amyloid ligand [11C]PIB, we explored in vivo imaging of tau and amyloid pathology in TBI patients.

Methods: Three patients with repetitive mild TBI (2 wrestlers, 1 kick boxer), two patients with single severe TBI (1 diffuse axonal injury, 1 acute subdural hematoma) and 20 age-matched healthy controls (HCs) underwent MRI and PET scans using [11C]PBB3 and [11C]PIB. For each PET data, standardized uptake value ratio (SUVR) using cerebellum as a reference region was calculated. Amyloid deposition was evaluated by visual assessment of SUVR images of [11C]PIB PET. Tau deposition was evaluated by visual assessment and VOI analysis of SUVR images of [11C]PBB3 PET. Cognitive impairments were also evaluated with neuropsychological tests.

Results: In HCs, none was [11C]PBB3- or [11C]PIB-positive. In TBI patients, memory impairment was the most frequent symptom. All TBI patients were [11C]PIB-negative, indicating absence of amyloid beta deposition. In contrast, four of five TBI patients showed high [11C]PBB3 binding in the medial temporal cortex. High [11C]PBB3 binding was also observed in the insular and the frontal cortex. Some of these [11C]PBB3-binding regions exhibited local cortical atrophy. Cortical atrophy was present in some of these regions.

Conclusions: These preliminary findings provided the evidence of TBI-induced tau pathology consistent with postmortem studies.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 Annual Meeting of Society of Biological Psychiatry
発表年月日
日付 2015-05-16
日付タイプ Issued
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