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Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB
https://repo.qst.go.jp/records/65826
https://repo.qst.go.jp/records/65826fd3202ab-f2b5-44a2-9f84-432b62f6fa28
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-05 | |||||
| タイトル | ||||||
| タイトル | Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takahata, Keisuke
× Takahata, Keisuke× Shimada, Hitoshi× Higuchi, Makoto× Shinotoh, Hitoshi× Kimura, Yasuyuki× Kitamura, Soichiro× Endo, Hironobu× Niwa, Fumitoshi× Moriguchi, Sho× Ichise, Masanori× Sahara, Naruhiko× Mimura, Masaru× Kato, Motoichiro× Yamada, Makiko× Suhara, Tetsuya× Takahata, Keisuke× Shimada, Hitoshi× Higuchi, Makoto× Shinoto, Hitoshi× Kimura, Yasuyuki× Kitamura, Soichiro× Endo, Hironobu× Niwa, Fumitoshi× Moriguchi, Sho× Ichise, Masanori× Sahara, Naruhiko× Mimura, Masaru× Kato, Motoichiro× Yamada, Makiko× Suhara, Tetsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Backgrounds: Chronic traumatic encephalopathy (CTE) is a delayed-onset neurodegenerative disease, which occurs several years after traumatic brain injury (TBI). Pathologically, CTE is characterized by abnormal accumulations including tau changes, amyloid-beta proteins. Using a novel tau ligand [11C]PBB3 and amyloid ligand [11C]PIB, we explored in vivo imaging of tau and amyloid pathology in TBI patients. Methods: Three patients with repetitive mild TBI (2 wrestlers, 1 kick boxer), two patients with single severe TBI (1 diffuse axonal injury, 1 acute subdural hematoma) and 20 age-matched healthy controls (HCs) underwent MRI and PET scans using [11C]PBB3 and [11C]PIB. For each PET data, standardized uptake value ratio (SUVR) using cerebellum as a reference region was calculated. Amyloid deposition was evaluated by visual assessment of SUVR images of [11C]PIB PET. Tau deposition was evaluated by visual assessment and VOI analysis of SUVR images of [11C]PBB3 PET. Cognitive impairments were also evaluated with neuropsychological tests. Results: In HCs, none was [11C]PBB3- or [11C]PIB-positive. In TBI patients, memory impairment was the most frequent symptom. All TBI patients were [11C]PIB-negative, indicating absence of amyloid beta deposition. In contrast, four of five TBI patients showed high [11C]PBB3 binding in the medial temporal cortex. High [11C]PBB3 binding was also observed in the insular and the frontal cortex. Some of these [11C]PBB3-binding regions exhibited local cortical atrophy. Cortical atrophy was present in some of these regions. Conclusions: These preliminary findings provided the evidence of TBI-induced tau pathology consistent with postmortem studies. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Annual Meeting of Society of Biological Psychiatry | |||||
| 発表年月日 | ||||||
| 日付 | 2015-05-16 | |||||
| 日付タイプ | Issued | |||||
