{"_buckets": {"deposit": "252dc0e0-1268-4377-ba89-be0577875b50"}, "_deposit": {"created_by": 1, "id": "65826", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "65826"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00065826", "sets": ["29"]}, "author_link": ["836612", "836622", "836614", "836635", "836616", "836633", "836624", "836617", "836634", "836609", "836626", "836620", "836613", "836619", "836632", "836627", "836621", "836629", "836631", "836623", "836615", "836608", "836628", "836606", "836607", "836611", "836618", "836630", "836625", "836610"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2015-05-16", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Backgrounds: Chronic traumatic encephalopathy (CTE) is a delayed-onset neurodegenerative disease, which occurs several years after traumatic brain injury (TBI). Pathologically, CTE is characterized by abnormal accumulations including tau changes, amyloid-beta proteins. Using a novel tau ligand [11C]PBB3 and amyloid ligand [11C]PIB, we explored in vivo imaging of tau and amyloid pathology in TBI patients.\n\nMethods: Three patients with repetitive mild TBI (2 wrestlers, 1 kick boxer), two patients with single severe TBI (1 diffuse axonal injury, 1 acute subdural hematoma) and 20 age-matched healthy controls (HCs) underwent MRI and PET scans using [11C]PBB3 and [11C]PIB. For each PET data, standardized uptake value ratio (SUVR) using cerebellum as a reference region was calculated. Amyloid deposition was evaluated by visual assessment of SUVR images of [11C]PIB PET. Tau deposition was evaluated by visual assessment and VOI analysis of SUVR images of [11C]PBB3 PET. Cognitive impairments were also evaluated with neuropsychological tests.\n\nResults: In HCs, none was [11C]PBB3- or [11C]PIB-positive. In TBI patients, memory impairment was the most frequent symptom. All TBI patients were [11C]PIB-negative, indicating absence of amyloid beta deposition. In contrast, four of five TBI patients showed high [11C]PBB3 binding in the medial temporal cortex. High [11C]PBB3 binding was also observed in the insular and the frontal cortex. Some of these [11C]PBB3-binding regions exhibited local cortical atrophy. Cortical atrophy was present in some of these regions.\n\nConclusions: These preliminary findings provided the evidence of TBI-induced tau pathology consistent with postmortem studies.\n", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要（会議名, 開催地, 会期, 主催者等）", "attribute_value_mlt": [{"subitem_description": "Annual Meeting of Society of Biological Psychiatry", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takahata, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "836606", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "836607", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "836608", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinotoh, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "836609", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "836610", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro"}], "nameIdentifiers": [{"nameIdentifier": "836611", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo, Hironobu"}], "nameIdentifiers": [{"nameIdentifier": "836612", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Fumitoshi"}], "nameIdentifiers": [{"nameIdentifier": "836613", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Moriguchi, Sho"}], "nameIdentifiers": [{"nameIdentifier": "836614", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori"}], "nameIdentifiers": [{"nameIdentifier": "836615", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahara, Naruhiko"}], "nameIdentifiers": [{"nameIdentifier": "836616", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mimura, Masaru"}], "nameIdentifiers": [{"nameIdentifier": "836617", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Motoichiro"}], "nameIdentifiers": [{"nameIdentifier": "836618", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Makiko"}], "nameIdentifiers": [{"nameIdentifier": "836619", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "836620", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahata, Keisuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836621", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836622", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836623", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinoto, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836624", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836625", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836626", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo, Hironobu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836627", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Fumitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836628", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Moriguchi, Sho", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836629", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836630", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahara, Naruhiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836631", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mimura, Masaru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836632", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Motoichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836633", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Makiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836634", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836635", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB"}]}, "item_type_id": "10005", "owner": "1", "path": ["29"], "permalink_uri": "https://repo.qst.go.jp/records/65826", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-05"}, "publish_date": "2015-08-05", "publish_status": "0", "recid": "65826", "relation": {}, "relation_version_is_last": true, "title": ["Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB"], "weko_shared_id": -1}