ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "252dc0e0-1268-4377-ba89-be0577875b50"}, "_deposit": {"created_by": 1, "id": "65826", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "65826"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00065826", "sets": ["29"]}, "author_link": ["836612", "836622", "836614", "836635", "836616", "836633", "836624", "836617", "836634", "836609", "836626", "836620", "836613", "836619", "836632", "836627", "836621", "836629", "836631", "836623", "836615", "836608", "836628", "836606", "836607", "836611", "836618", "836630", "836625", "836610"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2015-05-16", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Backgrounds: Chronic traumatic encephalopathy (CTE) is a delayed-onset neurodegenerative disease, which occurs several years after traumatic brain injury (TBI). Pathologically, CTE is characterized by abnormal accumulations including tau changes, amyloid-beta proteins. Using a novel tau ligand [11C]PBB3 and amyloid ligand [11C]PIB, we explored in vivo imaging of tau and amyloid pathology in TBI patients.\n\nMethods: Three patients with repetitive mild TBI (2 wrestlers, 1 kick boxer), two patients with single severe TBI (1 diffuse axonal injury, 1 acute subdural hematoma) and 20 age-matched healthy controls (HCs) underwent MRI and PET scans using [11C]PBB3 and [11C]PIB. For each PET data, standardized uptake value ratio (SUVR) using cerebellum as a reference region was calculated. Amyloid deposition was evaluated by visual assessment of SUVR images of [11C]PIB PET. Tau deposition was evaluated by visual assessment and VOI analysis of SUVR images of [11C]PBB3 PET. Cognitive impairments were also evaluated with neuropsychological tests.\n\nResults: In HCs, none was [11C]PBB3- or [11C]PIB-positive. In TBI patients, memory impairment was the most frequent symptom. All TBI patients were [11C]PIB-negative, indicating absence of amyloid beta deposition. In contrast, four of five TBI patients showed high [11C]PBB3 binding in the medial temporal cortex. High [11C]PBB3 binding was also observed in the insular and the frontal cortex. Some of these [11C]PBB3-binding regions exhibited local cortical atrophy. Cortical atrophy was present in some of these regions.\n\nConclusions: These preliminary findings provided the evidence of TBI-induced tau pathology consistent with postmortem studies.\n", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要(会議名, 開催地, 会期, 主催者等)", "attribute_value_mlt": [{"subitem_description": "Annual Meeting of Society of Biological Psychiatry", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takahata, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "836606", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "836607", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "836608", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinotoh, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "836609", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "836610", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro"}], "nameIdentifiers": [{"nameIdentifier": "836611", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo, Hironobu"}], "nameIdentifiers": [{"nameIdentifier": "836612", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Fumitoshi"}], "nameIdentifiers": [{"nameIdentifier": "836613", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Moriguchi, Sho"}], "nameIdentifiers": [{"nameIdentifier": "836614", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori"}], "nameIdentifiers": [{"nameIdentifier": "836615", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahara, Naruhiko"}], "nameIdentifiers": [{"nameIdentifier": "836616", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mimura, Masaru"}], "nameIdentifiers": [{"nameIdentifier": "836617", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Motoichiro"}], "nameIdentifiers": [{"nameIdentifier": "836618", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Makiko"}], "nameIdentifiers": [{"nameIdentifier": "836619", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "836620", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahata, Keisuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836621", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836622", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836623", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinoto, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836624", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836625", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836626", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo, Hironobu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836627", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Fumitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836628", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Moriguchi, Sho", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836629", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836630", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahara, Naruhiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836631", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mimura, Masaru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836632", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Motoichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836633", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Makiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836634", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "836635", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB"}]}, "item_type_id": "10005", "owner": "1", "path": ["29"], "permalink_uri": "https://repo.qst.go.jp/records/65826", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-05"}, "publish_date": "2015-08-05", "publish_status": "0", "recid": "65826", "relation": {}, "relation_version_is_last": true, "title": ["Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB"], "weko_shared_id": -1}
  1. 学会発表・講演等
  2. 口頭発表

Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB

https://repo.qst.go.jp/records/65826
https://repo.qst.go.jp/records/65826
fd3202ab-f2b5-44a2-9f84-432b62f6fa28
Item type 会議発表用資料 / Presentation(1)
公開日 2015-08-05
タイトル
タイトル Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Takahata, Keisuke

× Takahata, Keisuke

WEKO 836606

Takahata, Keisuke

Search repository
Shimada, Hitoshi

× Shimada, Hitoshi

WEKO 836607

Shimada, Hitoshi

Search repository
Higuchi, Makoto

× Higuchi, Makoto

WEKO 836608

Higuchi, Makoto

Search repository
Shinotoh, Hitoshi

× Shinotoh, Hitoshi

WEKO 836609

Shinotoh, Hitoshi

Search repository
Kimura, Yasuyuki

× Kimura, Yasuyuki

WEKO 836610

Kimura, Yasuyuki

Search repository
Kitamura, Soichiro

× Kitamura, Soichiro

WEKO 836611

Kitamura, Soichiro

Search repository
Endo, Hironobu

× Endo, Hironobu

WEKO 836612

Endo, Hironobu

Search repository
Niwa, Fumitoshi

× Niwa, Fumitoshi

WEKO 836613

Niwa, Fumitoshi

Search repository
Moriguchi, Sho

× Moriguchi, Sho

WEKO 836614

Moriguchi, Sho

Search repository
Ichise, Masanori

× Ichise, Masanori

WEKO 836615

Ichise, Masanori

Search repository
Sahara, Naruhiko

× Sahara, Naruhiko

WEKO 836616

Sahara, Naruhiko

Search repository
Mimura, Masaru

× Mimura, Masaru

WEKO 836617

Mimura, Masaru

Search repository
Kato, Motoichiro

× Kato, Motoichiro

WEKO 836618

Kato, Motoichiro

Search repository
Yamada, Makiko

× Yamada, Makiko

WEKO 836619

Yamada, Makiko

Search repository
Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 836620

Suhara, Tetsuya

Search repository
Takahata, Keisuke

× Takahata, Keisuke

WEKO 836621

en Takahata, Keisuke

Search repository
Shimada, Hitoshi

× Shimada, Hitoshi

WEKO 836622

en Shimada, Hitoshi

Search repository
Higuchi, Makoto

× Higuchi, Makoto

WEKO 836623

en Higuchi, Makoto

Search repository
Shinoto, Hitoshi

× Shinoto, Hitoshi

WEKO 836624

en Shinoto, Hitoshi

Search repository
Kimura, Yasuyuki

× Kimura, Yasuyuki

WEKO 836625

en Kimura, Yasuyuki

Search repository
Kitamura, Soichiro

× Kitamura, Soichiro

WEKO 836626

en Kitamura, Soichiro

Search repository
Endo, Hironobu

× Endo, Hironobu

WEKO 836627

en Endo, Hironobu

Search repository
Niwa, Fumitoshi

× Niwa, Fumitoshi

WEKO 836628

en Niwa, Fumitoshi

Search repository
Moriguchi, Sho

× Moriguchi, Sho

WEKO 836629

en Moriguchi, Sho

Search repository
Ichise, Masanori

× Ichise, Masanori

WEKO 836630

en Ichise, Masanori

Search repository
Sahara, Naruhiko

× Sahara, Naruhiko

WEKO 836631

en Sahara, Naruhiko

Search repository
Mimura, Masaru

× Mimura, Masaru

WEKO 836632

en Mimura, Masaru

Search repository
Kato, Motoichiro

× Kato, Motoichiro

WEKO 836633

en Kato, Motoichiro

Search repository
Yamada, Makiko

× Yamada, Makiko

WEKO 836634

en Yamada, Makiko

Search repository
Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 836635

en Suhara, Tetsuya

Search repository
抄録
内容記述タイプ Abstract
内容記述 Backgrounds: Chronic traumatic encephalopathy (CTE) is a delayed-onset neurodegenerative disease, which occurs several years after traumatic brain injury (TBI). Pathologically, CTE is characterized by abnormal accumulations including tau changes, amyloid-beta proteins. Using a novel tau ligand [11C]PBB3 and amyloid ligand [11C]PIB, we explored in vivo imaging of tau and amyloid pathology in TBI patients.

Methods: Three patients with repetitive mild TBI (2 wrestlers, 1 kick boxer), two patients with single severe TBI (1 diffuse axonal injury, 1 acute subdural hematoma) and 20 age-matched healthy controls (HCs) underwent MRI and PET scans using [11C]PBB3 and [11C]PIB. For each PET data, standardized uptake value ratio (SUVR) using cerebellum as a reference region was calculated. Amyloid deposition was evaluated by visual assessment of SUVR images of [11C]PIB PET. Tau deposition was evaluated by visual assessment and VOI analysis of SUVR images of [11C]PBB3 PET. Cognitive impairments were also evaluated with neuropsychological tests.

Results: In HCs, none was [11C]PBB3- or [11C]PIB-positive. In TBI patients, memory impairment was the most frequent symptom. All TBI patients were [11C]PIB-negative, indicating absence of amyloid beta deposition. In contrast, four of five TBI patients showed high [11C]PBB3 binding in the medial temporal cortex. High [11C]PBB3 binding was also observed in the insular and the frontal cortex. Some of these [11C]PBB3-binding regions exhibited local cortical atrophy. Cortical atrophy was present in some of these regions.

Conclusions: These preliminary findings provided the evidence of TBI-induced tau pathology consistent with postmortem studies.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 Annual Meeting of Society of Biological Psychiatry
発表年月日
日付 2015-05-16
日付タイプ Issued
戻る
0
views
See details
Views

Versions

Ver.1 2023-05-15 18:22:52.748925
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3