{"created":"2023-05-15T14:48:01.771854+00:00","id":65826,"links":{},"metadata":{"_buckets":{"deposit":"252dc0e0-1268-4377-ba89-be0577875b50"},"_deposit":{"created_by":1,"id":"65826","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65826"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065826","sets":["10:29"]},"author_link":["836612","836622","836614","836635","836616","836633","836624","836617","836634","836609","836626","836620","836613","836619","836632","836627","836621","836629","836631","836623","836615","836608","836628","836606","836607","836611","836618","836630","836625","836610"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-05-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Backgrounds: Chronic traumatic encephalopathy (CTE) is a delayed-onset neurodegenerative disease, which occurs several years after traumatic brain injury (TBI). Pathologically, CTE is characterized by abnormal accumulations including tau changes, amyloid-beta proteins. Using a novel tau ligand [11C]PBB3 and amyloid ligand [11C]PIB, we explored in vivo imaging of tau and amyloid pathology in TBI patients.\n\nMethods: Three patients with repetitive mild TBI (2 wrestlers, 1 kick boxer), two patients with single severe TBI (1 diffuse axonal injury, 1 acute subdural hematoma) and 20 age-matched healthy controls (HCs) underwent MRI and PET scans using [11C]PBB3 and [11C]PIB. For each PET data, standardized uptake value ratio (SUVR) using cerebellum as a reference region was calculated. Amyloid deposition was evaluated by visual assessment of SUVR images of [11C]PIB PET. Tau deposition was evaluated by visual assessment and VOI analysis of SUVR images of [11C]PBB3 PET. Cognitive impairments were also evaluated with neuropsychological tests.\n\nResults: In HCs, none was [11C]PBB3- or [11C]PIB-positive. In TBI patients, memory impairment was the most frequent symptom. All TBI patients were [11C]PIB-negative, indicating absence of amyloid beta deposition. In contrast, four of five TBI patients showed high [11C]PBB3 binding in the medial temporal cortex. High [11C]PBB3 binding was also observed in the insular and the frontal cortex. Some of these [11C]PBB3-binding regions exhibited local cortical atrophy. Cortical atrophy was present in some of these regions.\n\nConclusions: These preliminary findings provided the evidence of TBI-induced tau pathology consistent with postmortem studies.\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Annual Meeting of Society of Biological Psychiatry","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahata, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"836606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"836607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"836608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinotoh, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"836609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"836610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro"}],"nameIdentifiers":[{"nameIdentifier":"836611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Hironobu"}],"nameIdentifiers":[{"nameIdentifier":"836612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niwa, Fumitoshi"}],"nameIdentifiers":[{"nameIdentifier":"836613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moriguchi, Sho"}],"nameIdentifiers":[{"nameIdentifier":"836614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"836615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko"}],"nameIdentifiers":[{"nameIdentifier":"836616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mimura, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"836617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Motoichiro"}],"nameIdentifiers":[{"nameIdentifier":"836618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Makiko"}],"nameIdentifiers":[{"nameIdentifier":"836619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"836620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahata, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinoto, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Hironobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niwa, Fumitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moriguchi, Sho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836630","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mimura, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836632","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Motoichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Makiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"836635","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-05"},"publish_date":"2015-08-05","publish_status":"0","recid":"65826","relation_version_is_last":true,"title":["Imaging of Tau and Amyloid Pathology in Patients with Traumatic Brain Injury: A PET Study Usinig [11C]PBB3 and [11C]PIB"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:52:58.367158+00:00"}